Sorption and desorption behavior of hydroxychloroquine and ivermectin in WWTP sludge: kinetic and equilibrium insights

IF 2.4 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of chemical technology and biotechnology Pub Date : 2025-08-20 DOI:10.1002/jctb.70047

Bruna Giovana Locatelli, Juliane Maria Bergamin Bocardi, Ismael Laurindo Costa Junior, Adelmo Lowe Pletsch

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引用次数: 0

Abstract

BACKGROUND

Domestic sewage is one of the main pathways for the introduction of pharmaceutical contaminants into environmental compartments. During the COVID-19 pandemic, the consumption of medications such as hydroxychloroquine (HCQ) and ivermectin (IVM) increased significantly, resulting in a greater presence of these substances in ecosystems. Considering the existing knowledge gaps regarding the environmental impacts and ecological behavior of these compounds during this period, this study aimed to investigate the sorption and desorption kinetics and equilibrium of HCQ and IVM in sludge from domestic wastewater treatment plants (WWTPs).

RESULTS

The pseudo-second-order model best fit the kinetic sorption data for both HCQ (R² = 0.91–0.99) and IVM (R² = 0.94–0.99), indicating that chemisorption may be the dominant mechanism. Equilibrium data were better described by the Langmuir isotherm (R² = 0.85–0.99 for HCQ and R² = 0.94–0.99 for IVM), suggesting monolayer adsorption on a homogeneous surface. The highest specific sorption capacities observed were 20.04 mg g⁻¹ for HCQ and 23.29 mg g⁻¹ for IVM. The maximum desorption percentage was 49.15% for HCQ, while no desorption of IVM was detected under experimental conditions.

CONCLUSION

Both analytes exhibited sorptive interactions with sewage sludge, with IVM demonstrating a stronger affinity. The findings highlight concerns about the persistence and accumulation of pharmaceutical contaminants in the environment due to discharges from WWTPs. © 2025 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).

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羟氯喹和伊维菌素在污水处理厂污泥中的吸附和解吸行为：动力学和平衡的见解

生活污水是将药物污染物引入环境隔间的主要途径之一。在2019冠状病毒病大流行期间，羟氯喹（HCQ）和伊维菌素（IVM）等药物的消费量显著增加，导致生态系统中这些物质的含量增加。考虑到这一时期对这些化合物的环境影响和生态行为的现有知识空白，本研究旨在研究生活污水处理厂（WWTPs）污泥中HCQ和IVM的吸附和解吸动力学和平衡。结果拟二阶模型与HCQ （R2 = 0.91 ~ 0.99）和IVM （R2 = 0.94 ~ 0.99）的吸附动力学数据拟合最佳，表明化学吸附可能是主要吸附机理。Langmuir等温线（R2 = 0.85-0.99, IVM = 0.94-0.99）更好地描述了平衡数据，表明单层吸附在均匀表面上。HCQ和IVM的最高比吸附量分别为20.04 mg g−1和23.29 mg g−1。HCQ的最大解吸率为49.15%，而IVM在实验条件下没有解吸。结论两种分析物均与污泥表现出吸附相互作用，其中IVM表现出更强的亲和力。研究结果强调了人们对污水处理厂排放的药物污染物在环境中持续存在和积累的担忧。©2025作者。由John Wiley &； Sons Ltd代表美国化学工业学会（SCI）出版的化学技术与生物技术杂志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.