Synthesis and Docking Study of 6-Substituted Indolo[2,3-b]quinoxalines

Abstract

6-(2-Bromoethyl)-6H-indolo[2,3-b]quinoxaline was synthesized and reacted with arylamines to obtain N-(2-[6H-indolo[2,3-b]quinoxalin-6-yl)ethyl]arylamines and N,N-disubstituted 4-methylaniline. Previosly unknown 6-vinyl- and 6-(2-azidoethyl) derivatives of 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline and indolo[2,3-b]quinoxaline–pyrimidine and 1,2-bis(6H-indolo[2,3-b]quinoxalin-6-yl)ethane hybrids were also synthesized. Molecular docking studies of the synthesized indolo[2,3-b]quinoxaline derivatives against 4 different receptors indicated high predicted activity for the indoloquinoxaline–pyrimidine conjugate.