Emerging role of cancer-associated fibroblasts in the premetastatic niche

IF 33.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-10-08 DOI:10.1186/s12943-025-02461-0

Shuaixi Yang, Ying Guo, Jiachi Jia, Wenming Cui, Xinhao Zhang, Yuhang Wang, Zhiyuan Xie, Yingshuai Fang, Xianfei Ding, Lei Chang, Ying Liu

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引用次数: 0

Abstract

In recent years, tumor metastasis has become one of the major causes of high recurrence and mortality in cancer patients. Owing to multiorgan involvement, metastatic cancers are now clinically difficult to cure and often have a very poor prognosis. In recent years, an increasing number of studies have shown that the establishment of a premetastatic niche (PMN) is necessary for tumor metastasis. Cancer-associated fibroblasts (CAFs), which are closely related to tumor development, are deeply involved in regulating PMN establishment. By regulating EVs, metabolism and other pathways, CAFs actively shape microenvironmental characteristics, including inflammation, angiogenesis, increased vascular permeability, lymphangiogenesis, immunosuppression and extracellular matrix (ECM) remodeling. With the development of single-cell sequencing technology, our understanding of the role and significance of heterogeneous CAFs in the PMN has improved. Multiple therapeutic strategies targeting CAFs in the PMN have also been developed. This article focuses on the crosstalk of different subtypes of CAFs with other stromal cells, the mechanisms by which CAFs of different origins mediate PMN formation, and the emerging cancer therapeutic strategies by which CAFs have been targeted in recent years.

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癌症相关成纤维细胞在转移前生态位中的新作用

近年来，肿瘤转移已成为癌症患者高复发率和死亡率的主要原因之一。由于多器官受累，转移性癌症现在临床上很难治愈，而且往往预后很差。近年来，越来越多的研究表明，转移前生态位（premetastatic niche， PMN）的建立是肿瘤转移的必要条件。癌症相关成纤维细胞（Cancer-associated fibroblasts, CAFs）与肿瘤的发展密切相关，并深度参与了PMN的建立。通过调节ev、代谢等途径，CAFs积极塑造微环境特征，包括炎症、血管生成、血管通透性增加、淋巴管生成、免疫抑制和细胞外基质（ECM）重塑。随着单细胞测序技术的发展，我们对异质CAFs在PMN中的作用和意义的认识有所提高。针对PMN中caf的多种治疗策略也被开发出来。本文将重点介绍不同亚型的CAFs与其他基质细胞的串扰，不同来源的CAFs介导PMN形成的机制，以及近年来CAFs靶向的新癌症治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.