Chalcogen functionalized pyrimidine synthesis by three-component free radical chalcogenation and pyrimidine ring construction

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-10-08 DOI:10.1039/d5qo01206f

Jingfeng Ye, Gengxin Li, Changfeng Wan, Jie-Ping Wan

引用次数: 0

Abstract

A rather facile transition metal-free protocol for the synthesis of chalcogen functionalized pyrimidines has been established via three-component reactions of enaminones, disulfides/diselenide, and amidines/guanidine. The reactions proceed efficiently in the presence of I2/KOH, and provides particularly practical and broadly applicable access to chalcogented pyrimidines. The reaction mechanism involving a key chalcogen (sulfur)-centered free radical has been verified by control experiments.

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用三组分自由基加硫和嘧啶环构造法合成硫基功能化嘧啶

通过胺酮、二硫化物/二硒化物和脒/胍的三组分反应，建立了一种相当简单的无过渡金属合成硫基功能化嘧啶的方法。在I2/KOH的存在下，反应有效地进行，并提供了特别实用和广泛适用的含硫嘧啶的途径。通过对照实验验证了该反应涉及一个以硫（硫）为中心的关键自由基的机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.