{"title":"Anal plasmablastic lymphoma with complete response to antiretroviral therapy - a case report.","authors":"D Montwedi, M Ramabulana, N Khan","doi":"10.36303/SAJS.00917","DOIUrl":null,"url":null,"abstract":"<p><strong>Summary: </strong>A 40-year-old male, known to be positive with the human immunodeficiency virus (HIV), presented with a large perianal mass and faecal obstruction. His CD4 count was 121 cells/mm3 suggesting advanced HIV disease, and he was started on second-line antiretroviral therapy. Magnetic resonance imaging (MRI) confirmed a large mass involving the anorectal junction. A biopsy of the tumor revealed a plasmablastic lymphoma (PBL). A diverting colostomy was performed for faecal obstruction. While awaiting chemotherapy treatment, the tumour rapidly decreased in size with complete clinical resolution. PBL is rare and has a dismal prognosis. Spontaneous regression of PBL has been reported but regression on second-line antiretroval therapy has not been previously described.</p>","PeriodicalId":51161,"journal":{"name":"South African Journal of Surgery","volume":"63 2","pages":"100-102"},"PeriodicalIF":0.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Journal of Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36303/SAJS.00917","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Summary: A 40-year-old male, known to be positive with the human immunodeficiency virus (HIV), presented with a large perianal mass and faecal obstruction. His CD4 count was 121 cells/mm3 suggesting advanced HIV disease, and he was started on second-line antiretroviral therapy. Magnetic resonance imaging (MRI) confirmed a large mass involving the anorectal junction. A biopsy of the tumor revealed a plasmablastic lymphoma (PBL). A diverting colostomy was performed for faecal obstruction. While awaiting chemotherapy treatment, the tumour rapidly decreased in size with complete clinical resolution. PBL is rare and has a dismal prognosis. Spontaneous regression of PBL has been reported but regression on second-line antiretroval therapy has not been previously described.
期刊介绍：
The South African Journal of Surgery (SAJS) is a quarterly, general surgical journal. It carries research articles and letters, editorials, clinical practice and other surgical articles and personal opinion, South African health-related news, obituaries and general correspondence.
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