Protective effect of artichoke (Cynara scolymus L.) leaf and receptaculum extracts against hepatic encephalopathy in bile duct ligated rats.

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolic brain disease Pub Date : 2025-10-07 DOI:10.1007/s11011-025-01701-y

Özkan Kam, Berna Terzioğlu Bebitoğlu, Göksel Şener, Elif Oğuz, Nurettin Fatih Erdoğan, Andaç Kılıçkap, Büşra Ertaş, Ali Şen, İsmail Şenkardeş, Burçin İrem Abas, Özge Çevik, Feriha Ercan, Hilal Ünlü, Nebile Hatiboğlu

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引用次数: 0

Abstract

Hepatic encephalopathy (HE), complication of liver dysfunction, leads to neurocognitive impairments. Artichoke (Cynara scolymus L.) has been traditionally used for its antioxidant, anti-inflammatory and hepatoprotective properties. This study evaluates artichoke leaf and receptaculum extracts in cholestasis and HE in a rat model. Wistar rats were divided into 6 groups: sham-control, bile duct ligation (BDL), and BDL with low/high-dose leaf or receptaculum extracts. After BDL, physiological saline and extracts (250/500 mg/kg) were administered orally for 28 days. Cognitive activity was evaluated using Morris water maze and novel object recognition tests on day 28. Artichoke extract regulated liver enzymes and bilirubin at high-doses and significantly increased antioxidant enzyme activities reduced by BDL. Elevated 8-Hydroxyguanosine (8-OHdG) levels decreased in liver and brain tissues. Similarly, artichoke extracts reduced cytokine and hydroxyproline (HP) levels elevated by cholestasis. Following BDL, Na⁺/K⁺-ATPase levels in brain and liver tissues decreased, while artichoke extract reversed this. Artichoke, particularly high-dose receptaculum, improved impaired performance and increased time in the target quadrant after BDL. Both artichoke leaf and receptaculum extracts improved recognition. Artichoke treatments, especially high-dose receptaculum, reduced hepatic and neuronal damage and improved histological appearance. These findings highlight the therapeutic potential of artichoke extracts for liver fibrosis and related neurocognitive disorders.

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洋蓟叶及托叶提取物对胆管结扎大鼠肝性脑病的保护作用。

肝性脑病（HE）是肝功能障碍的并发症，可导致神经认知障碍。洋蓟（Cynara scolymus L.）因其抗氧化、抗炎和保护肝脏的特性而被传统地使用。本研究评价了洋蓟叶和托叶提取物对大鼠胆汁淤积和HE的影响。Wistar大鼠分为6组：假对照、胆管结扎（BDL）组和低/高剂量叶或花托提取物组。BDL后，生理盐水和提取物（250/500 mg/kg）口服28天。第28天采用Morris水迷宫和新物体识别测试评估认知活动。大剂量洋蓟提取物调节肝酶和胆红素，显著提高BDL所致抗氧化酶活性。肝脏和脑组织中升高的8-羟基鸟苷（8-OHdG）水平下降。同样，朝鲜蓟提取物降低了因胆汁淤积而升高的细胞因子和羟脯氨酸（HP）水平。BDL后，脑和肝组织中的Na + /K + - atp酶水平下降，而朝鲜蓟提取物逆转了这一趋势。洋蓟，特别是高剂量的受体，改善了受损的表现，并增加了BDL后目标象限的时间。洋蓟叶和花托提取物均能提高识别能力。洋蓟治疗，特别是大剂量受体，减少肝脏和神经元损伤，改善组织学外观。这些发现强调了洋蓟提取物对肝纤维化和相关神经认知障碍的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolic brain disease 医学-内分泌学与代谢

CiteScore

5.90

自引率

5.60%

发文量

248

审稿时长

6-12 weeks

期刊介绍： Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.