From mechanisms to markers: role of pyroptosis in revolutionizing thyroid cancer care.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-10-06 DOI:10.1038/s41420-025-02741-0

Ningxin Wang, Yuying Chen, Guhan Luo, Dingcun Luo

{"title":"From mechanisms to markers: role of pyroptosis in revolutionizing thyroid cancer care.","authors":"Ningxin Wang, Yuying Chen, Guhan Luo, Dingcun Luo","doi":"10.1038/s41420-025-02741-0","DOIUrl":null,"url":null,"abstract":"<p><p>The global incidence of thyroid cancer, especially papillary thyroid cancer, has increased in recent decades, making it a significant global health issue. Pyroptosis, an important form of programmed cell death, is characterized by pore formation in the cell membrane, membrane rupture, cell swelling, and the subsequent release of cellular contents. Factors released during this process, such as interleukin-1β and interleukin-18, amplify inflammatory effects and trigger immune activation. Increasing evidence indicates that pyroptosis has either tumour-promoting or tumour-suppressing effects at various stages of tumour progression, which has garnered significant attention and warrants further investigation. Thus, harnessing the tumour-inhibitory effects while mitigating the tumour-promoting effects of pyroptosis represents a promising therapeutic strategy for the clinical management of thyroid cancer. Furthermore, pyroptosis-related genes are significantly correlated with the prognosis of thyroid cancer. Therefore, this review provides an overview of the current research regarding the role of pyroptosis in thyroid cancer, focusing on its mechanisms, therapeutic targets, and predictive biomarkers. These findings highlight the importance of pyroptosis in thyroid cancer and offer valuable insights for the development of innovative treatment strategies and accurate prognostic markers.</p>","PeriodicalId":9735,"journal":{"name":"Cell Death Discovery","volume":"11 1","pages":"439"},"PeriodicalIF":7.0000,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501357/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Death Discovery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41420-025-02741-0","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The global incidence of thyroid cancer, especially papillary thyroid cancer, has increased in recent decades, making it a significant global health issue. Pyroptosis, an important form of programmed cell death, is characterized by pore formation in the cell membrane, membrane rupture, cell swelling, and the subsequent release of cellular contents. Factors released during this process, such as interleukin-1β and interleukin-18, amplify inflammatory effects and trigger immune activation. Increasing evidence indicates that pyroptosis has either tumour-promoting or tumour-suppressing effects at various stages of tumour progression, which has garnered significant attention and warrants further investigation. Thus, harnessing the tumour-inhibitory effects while mitigating the tumour-promoting effects of pyroptosis represents a promising therapeutic strategy for the clinical management of thyroid cancer. Furthermore, pyroptosis-related genes are significantly correlated with the prognosis of thyroid cancer. Therefore, this review provides an overview of the current research regarding the role of pyroptosis in thyroid cancer, focusing on its mechanisms, therapeutic targets, and predictive biomarkers. These findings highlight the importance of pyroptosis in thyroid cancer and offer valuable insights for the development of innovative treatment strategies and accurate prognostic markers.

查看原文本刊更多论文

从机制到标志物：焦亡在革命性甲状腺癌治疗中的作用。

近几十年来，全球甲状腺癌，特别是乳头状甲状腺癌的发病率有所增加，使其成为一个重大的全球健康问题。焦亡是细胞程序性死亡的一种重要形式，其特征是细胞膜上形成孔，膜破裂，细胞肿胀，随后释放细胞内容物。在此过程中释放的因子，如白细胞介素-1β和白细胞介素-18，放大炎症效应并触发免疫激活。越来越多的证据表明，焦亡在肿瘤进展的各个阶段都有促进或抑制肿瘤的作用，这已经引起了人们的极大关注，值得进一步研究。因此，利用肿瘤抑制作用，同时减轻焦亡的促肿瘤作用，是甲状腺癌临床治疗的一种有希望的治疗策略。此外，热解相关基因与甲状腺癌的预后有显著相关性。因此，本文综述了目前关于焦亡在甲状腺癌中的作用的研究，重点介绍了其机制、治疗靶点和预测生物标志物。这些发现强调了甲状腺癌中焦亡的重要性，并为开发创新的治疗策略和准确的预后标志物提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.