Sodium dithionite mediated reductive N-acetylation/formylation of nitroarenes employing DMAc/DMF as acetyl/formyl surrogates

IF 4.7 1区 化学 Q1 CHEMISTRY, ORGANIC
Amitava Hazra, Komal Mendhe, Joydev K. Laha
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引用次数: 0

Abstract

The present invention discloses a unified strategy for N-acetylation/formylation directly from nitroarenes employing solvents DMAc/DMF as the source of acetyl/formyl groups in the presence of sodium dithionite as the exclusive reagent. Unlike the conventional N-acetylation/formylation of anilines, the method uses precursor nitroarenes to form acetanilides/formanilides via in situ reduction to anilines. The regioselectivity, application to drug molecules, tandem process, and dual role of the reagent are the key features of the method.
二亚硝酸钠以DMAc/DMF作为乙酰基/甲酰代物介导硝基芳烃的n -乙酰化/甲酰化反应
本发明公开了一种直接从硝基芳烃进行n -乙酰化/甲酰化的统一策略,采用溶剂DMAc/DMF作为乙酰基/甲酰基的来源,二亚硫酸钠作为专用试剂存在。与传统的苯胺的n -乙酰化/甲酰化不同,该方法使用前体硝基芳烃通过原位还原苯胺形成乙酰苯胺/酰胺苯胺。该方法的主要特点是试剂的区域选择性、适用于药物分子、串联过程和双重作用。
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来源期刊
Organic Chemistry Frontiers
Organic Chemistry Frontiers CHEMISTRY, ORGANIC-
CiteScore
7.90
自引率
11.10%
发文量
686
审稿时长
1 months
期刊介绍: Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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