{"title":"Sodium dithionite mediated reductive N-acetylation/formylation of nitroarenes employing DMAc/DMF as acetyl/formyl surrogates","authors":"Amitava Hazra, Komal Mendhe, Joydev K. Laha","doi":"10.1039/d5qo01199j","DOIUrl":null,"url":null,"abstract":"The present invention discloses a unified strategy for N-acetylation/formylation directly from nitroarenes employing solvents DMAc/DMF as the source of acetyl/formyl groups in the presence of sodium dithionite as the exclusive reagent. Unlike the conventional N-acetylation/formylation of anilines, the method uses precursor nitroarenes to form acetanilides/formanilides via in situ reduction to anilines. The regioselectivity, application to drug molecules, tandem process, and dual role of the reagent are the key features of the method.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"1 1","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5qo01199j","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The present invention discloses a unified strategy for N-acetylation/formylation directly from nitroarenes employing solvents DMAc/DMF as the source of acetyl/formyl groups in the presence of sodium dithionite as the exclusive reagent. Unlike the conventional N-acetylation/formylation of anilines, the method uses precursor nitroarenes to form acetanilides/formanilides via in situ reduction to anilines. The regioselectivity, application to drug molecules, tandem process, and dual role of the reagent are the key features of the method.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.