Nonlinear Association Between Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Diabetic Kidney Disease: Evidence from NHANES 2007-2018.

IF 2
Yi Wei, Chao Liu, Jiangyi Yu
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Abstract

Introduction: The relationship between uric acid to high-density cholesterol ratio (UHR) and diabetic kidney disease (DKD) is unclear. The aim of this study was to investigate the relationship between UHR and DKD in patients with diabetes mellitus (DM).

Methods: Analyses were conducted based on National Health and Nutrition Examination Survey (NHANES) data from the 2007-2018 cycle. We used multifactorial logistic regression to analyze the association between UHR and DKD. We performed restricted cubic splines (RCS) analyses to explore whether there was a nonlinear relationship between the two. In addition, we explored differences in this association between different subgroups.

Results: A total of 2,674 participants were included in the study. After adjusting for all confounding variables, multivariate logistic regression analysis revealed a significant correlation between UHR and DKD in patients with DM. RCS analysis further revealed a significant nonlinear association between UHR and DKD. Subgroup analysis showed that the association between UHR and DKD was consistent across different subgroups. In addition, the effect of UHR on DKD was significantly influenced by the level of BMI.

Discussion: This study explored the relationship between UHR and DKD, contributing to a better understanding of the significance of UHR in DKD.

Conclusion: Our study found a "J" nonlinear association between UHR and DKD in patients with DM.

尿酸与高密度脂蛋白胆固醇比值与糖尿病肾病的非线性关联:来自NHANES 2007-2018的证据
尿酸与高密度胆固醇比值(UHR)与糖尿病肾病(DKD)的关系尚不清楚。本研究旨在探讨糖尿病(DM)患者UHR与DKD之间的关系。方法:基于2007-2018年周期的国家健康与营养检查调查(NHANES)数据进行分析。我们使用多因素逻辑回归分析UHR和DKD之间的关系。我们进行了限制三次样条(RCS)分析,以探讨两者之间是否存在非线性关系。此外,我们还探讨了不同亚组之间这种关联的差异。结果:研究共纳入2674名参与者。在调整所有混杂变量后,多因素logistic回归分析显示糖尿病患者UHR和DKD之间存在显著相关性。RCS分析进一步显示UHR和DKD之间存在显著的非线性关联。亚组分析显示,UHR和DKD之间的关联在不同的亚组中是一致的。此外,UHR对DKD的影响受BMI水平的显著影响。讨论:本研究探讨了UHR与DKD之间的关系,有助于更好地理解UHR在DKD中的意义。结论:我们的研究发现糖尿病患者UHR和DKD之间存在“J”型非线性关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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