Efficacy and Safety of Platelet-Rich Plasma for Patients With Meniscal Injury: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

IF 2.5 3区医学 Q2 ORTHOPEDICS

Orthopaedic Journal of Sports Medicine Pub Date : 2025-10-03 eCollection Date: 2025-10-01 DOI:10.1177/23259671251371233

Jianshui Liang, Mingzhong Tu, Haitao Li, Wangzhu Chen, Chunjiang Wang

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引用次数: 0

Abstract

Background: Platelet-rich plasma (PRP) is widely used to promote healing and improve function in various musculoskeletal injuries. However, the efficacy and safety of PRP for meniscal injury remain unclear.

Purpose: To evaluate the effects of PRP in patients with meniscal injury.

Study design: Systematic review; Level of evidence, 2.

Methods: A comprehensive search was conducted in PubMed, Embase, Cochrane Library, Web of Science, Wanfang, and CNKI databases. Randomized controlled trials comparing PRP with placebo or no additional treatment in adult patients with meniscal injury were included. Outcome measures included the visual analog scale for knee pain, Lysholm score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee injury and Osteoarthritis Outcome Score (KOOS), treatment failure, and complications. Data were pooled using a random-effects model by incorporating the influence of heterogeneity.

Results: This meta-analysis included 18 randomized controlled trials involving a total of 1143 patients. The mean follow-up duration ranged from 3 to 12 months. PRP significantly reduced knee pain (mean difference [MD], -0.73; 95% CI, -0.91 to -0.55) and improved knee function, as indicated by higher Lysholm scores (MD, 6.77; 95% CI, 5.35 to 8.20) and KOOS (MD, 4.34; 95% CI, 1.35 to 7.32), and lower WOMAC scores (MD, -5.33; 95% CI, -8.10 to -2.56). Subgroup analyses suggested similar results in patients with and without concurrent knee osteoarthritis, with single and multiple PRP injection, and with follow-up duration of <12 and ≥12 months. In addition, PRP also reduced treatment failure rates (odds ratio, 0.26; 95% CI, 0.12 to 0.59), with no significant difference in complications.

Conclusion: PRP is effective in reducing pain and improving knee function in patients with meniscal injury.

Registration: CRD42024601679 (PROSPERO).

查看原文本刊更多论文

富血小板血浆治疗半月板损伤的疗效和安全性：随机对照试验的系统回顾和荟萃分析。

背景：富血小板血浆（PRP）被广泛用于促进各种肌肉骨骼损伤的愈合和改善功能。然而，PRP治疗半月板损伤的有效性和安全性尚不清楚。目的：评价PRP治疗半月板损伤的疗效。研究设计：系统评价；证据等级2。方法：综合检索PubMed、Embase、Cochrane Library、Web of Science、万方、CNKI等数据库。随机对照试验比较PRP与安慰剂或无额外治疗的半月板损伤成人患者。结果测量包括膝关节疼痛的视觉模拟量表、Lysholm评分、西安大略省和麦克马斯特大学骨关节炎指数（WOMAC）、膝关节损伤和骨关节炎结局评分（oos）、治疗失败和并发症。通过纳入异质性的影响，采用随机效应模型汇总数据。结果：本荟萃分析纳入18项随机对照试验，共1143例患者。平均随访时间为3 ~ 12个月。PRP显著减轻膝关节疼痛（平均差异[MD]， -0.73; 95% CI, -0.91至-0.55），改善膝关节功能，Lysholm评分较高（MD, 6.77; 95% CI， 5.35至8.20），kos评分较高（MD, 4.34; 95% CI， 1.35至7.32），WOMAC评分较低（MD, -5.33; 95% CI, -8.10至-2.56）。亚组分析显示，合并和不合并膝关节骨性关节炎患者、单次和多次PRP注射以及随访时间的结果相似。结论：PRP可有效减轻半月板损伤患者的疼痛和改善膝关节功能。注册号：CRD42024601679 （PROSPERO）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orthopaedic Journal of Sports Medicine Medicine-Orthopedics and Sports Medicine

CiteScore

4.30

自引率

7.70%

发文量

876

审稿时长

12 weeks

期刊介绍： The Orthopaedic Journal of Sports Medicine (OJSM), developed by the American Orthopaedic Society for Sports Medicine (AOSSM), is a global, peer-reviewed, open access journal that combines the interests of researchers and clinical practitioners across orthopaedic sports medicine, arthroscopy, and knee arthroplasty. Topics include original research in the areas of: -Orthopaedic Sports Medicine, including surgical and nonsurgical treatment of orthopaedic sports injuries -Arthroscopic Surgery (Shoulder/Elbow/Wrist/Hip/Knee/Ankle/Foot) -Relevant translational research -Sports traumatology/epidemiology -Knee and shoulder arthroplasty The OJSM also publishes relevant systematic reviews and meta-analyses. This journal is a member of the Committee on Publication Ethics (COPE).