Prognostic implications of cancer-associated fibroblasts and desmoplastic reaction in stage III colon cancer risk groups.

IF 2.6 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2025-10-05 DOI:10.1080/14796694.2025.2567845

Nazım Can Demircan, Mehmet Fatih Tekin, Tuğba Akın Telli, Rukiye Arıkan, Tuğba Başoğlu, Abdussamet Çelebi, Alper Yaşar, Selver Işık, Özlem Ercelep, Faysal Dane, Çiğdem Ataizi Çelikel, Perran Fulden Yumuk

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引用次数: 0

Abstract

Aim: Risk stratification is used to tailor adjuvant treatment in stage III colon cancer. Cancer associated fibroblasts (CAFs) and desmoplastic reaction (DR) contribute to tumor microenvironment and are associated with tumor progression. We aimed to assess the prognostic value of CAF markers and DR pattern in stage III colon cancer risk groups.

Materials and methods: Patients with curative surgery for stage III colon cancer were categorized as low-risk (pT1-3 and pN1) and high-risk (pT4 or pN2). Expressions of fibroblast activation protein α (FAPα), fibroblast specific protein-1 (S100A4) and α-smooth muscle actin (α-SMA) were evaluated semiquantitatively with H-scores. DR pattern was classified as immature, intermediate and mature. Cox regression models were used to determine hazard ratios (HRs) of prognostic factors.

Results: Within the study cohort (n = 172), 98 patients had high-risk and 74 had low-risk disease. In the low-risk group, high FAPα expression independently predicted DFS (HR = 3.06, p = 0.02). In the high-risk group, immature DR was an independent prognostic factor for both DFS (HR = 1.99, p = 0.02) and OS (HR = 2.04, p = 0.02).

Conclusion: FAPα as a surrogate marker of CAFs and DR pattern may have distinct prognostic impacts in stage III colon cancer risk groups and be utilized to refine prognosis further in these patients.

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癌症相关成纤维细胞和结缔组织增生反应在III期结肠癌危险人群中的预后意义

目的：风险分层用于调整III期结肠癌的辅助治疗。肿瘤相关成纤维细胞（CAFs）和结缔组织增生反应（DR）有助于肿瘤微环境的形成，并与肿瘤进展相关。我们的目的是评估CAF标志物和DR模式在III期结肠癌危险人群中的预后价值。材料与方法：将行根治性手术的III期结肠癌患者分为低危（pT1-3和pN1）和高危（pT4或pN2）。半定量评价成纤维细胞活化蛋白α (FAPα)、成纤维细胞特异性蛋白-1 （S100A4）和α-平滑肌肌动蛋白（α- sma）的表达。DR模式分为未成熟、中等和成熟。采用Cox回归模型确定预后因素的风险比（hr）。结果：在研究队列（n = 172）中，98例患者患有高危疾病，74例患者患有低危疾病。低危组FAPα高表达独立预测DFS （HR = 3.06, p = 0.02）。在高危组中，未成熟DR是DFS （HR = 1.99, p = 0.02）和OS （HR = 2.04, p = 0.02）的独立预后因素。结论：FAPα作为CAFs和DR模式的替代标志物可能对III期结肠癌危险人群的预后有明显影响，并可用于进一步改善这些患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.