Influence of MWCNT Concentration on Antibacterial and Simultaneous Electrochemical Sensing of Ascorbic Acid and Paracetamol for Ag-Doped TiO2 Composites

IF 2.8 4区化学 Q3 CHEMISTRY, PHYSICAL

Electrocatalysis Pub Date : 2025-08-16 DOI:10.1007/s12678-025-00975-1

Saima Rafique, Adnan Shafique, Farrukh Bashir Kayani, Rizwan Akram, Mozaffar Hussain, Zobia Noreen, Shazia Bashir

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Abstract

In the present work, a straightforward approach was adopted to synthesize concentration-dependent multiwall carbon nanotubes with silver-doped titanium oxide (Ag-TiO₂) composites. The antibacterial activity was examined against Gram-positive and Gram-negative bacteria, increasing from 12.5 to 16.5 mm for S. aureus, 20.5 to 26 mm for C. jejuni, and 19.5 to 25.5 mm for V. cholerae, incorporating 5% and 10% MWCNTs with Ag-TiO₂, respectively. An Ag-TiO₂-10% MWCNTs-GCE system was developed for the simultaneous detection of ascorbic acid (AA) and paracetamol (PA). Under optimal conditions, the sensor demonstrates linearity for AA (0.5–300 µM) and PA (0.01–500 µM) (n = 3), respectively. The corresponding detection limits for AA and PA were 0.038 and 0.008 μM. This electrochemical sensor exhibits tremendous promise for a variety of medical applications, particularly in AA and PA monitoring, and offers a straightforward and extremely sensitive approach for detecting AA and PA in human serum samples and pharmaceutical samples.

Graphical Abstract

查看原文本刊更多论文

MWCNT浓度对ag掺杂TiO2复合材料抗菌及同时电化学感应抗坏血酸和扑热息痛的影响

在本工作中，采用一种简单的方法，用掺银氧化钛（Ag-TiO2）复合材料合成了浓度依赖的多壁碳纳米管。对革兰氏阳性菌和革兰氏阴性菌的抑菌活性进行了检测，分别添加5%和10% MWCNTs与Ag-TiO2后，金黄色葡萄球菌的抑菌活性从12.5 mm增加到16.5 mm，空肠梭菌的抑菌活性从20.5 mm增加到26 mm，霍乱弧菌的抑菌活性从19.5 mm增加到25.5 mm。建立了一种同时检测抗坏血酸（AA）和扑热息痛（PA）的Ag-TiO2-10% MWCNTs-GCE体系。在最佳条件下，传感器分别对AA（0.5-300µM）和PA（0.01-500µM）呈线性（n = 3）。AA和PA的检出限分别为0.038和0.008 μM。这种电化学传感器在各种医学应用中表现出巨大的前景，特别是在AA和PA监测方面，并为检测人类血清样品和药物样品中的AA和PA提供了一种简单而极其敏感的方法。图形抽象

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来源期刊

Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

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