Understanding the burden of ANCA-associated vasculitis

IF 4.4 2区医学 Q1 RHEUMATOLOGY

Rheumatology Pub Date : 2025-10-06 DOI:10.1093/rheumatology/keaf520

Bernhard Hellmich

引用次数: 0

Abstract

Anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is a group of frequently relapsing systemic autoimmune disorders characterized by vasculitis-related organ damage and multiple comorbidities related to chronic inflammation. Advances in immunosuppression-based therapies for AAV have considerably improved remission rates, reduced the risk of relapse, and improved survival in patients with AAV. However, mortality remains high compared with the general population and the benefits of treatment are often offset by treatment-related comorbidities, organ damage and adverse effects, particularly infections. The aim of this review is to investigate the key contributors to disease burden in patients with AAV and to describe strategies for improving health-related quality of life.

查看原文本刊更多论文

了解anca相关血管炎的负担

抗中性粒细胞胞浆抗体相关血管炎（Anti-neutrophil cytoplasmic antibody-, ANCA-）相关血管炎（AAV）是一组经常复发的系统性自身免疫性疾病，其特征是血管炎相关器官损害和与慢性炎症相关的多种合并症。基于免疫抑制的AAV治疗的进展显著提高了AAV患者的缓解率，降低了复发风险，提高了生存率。然而，与一般人群相比，死亡率仍然很高，治疗的好处往往被与治疗有关的合并症、器官损害和不利影响，特别是感染所抵消。本综述的目的是调查AAV患者疾病负担的主要因素，并描述改善与健康相关的生活质量的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.