Association between life’s crucial 9 and stroke: results from the NHANES 2005–2018

IF 1.8 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2025-10-01 DOI:10.1016/j.jstrokecerebrovasdis.2025.108462

Xiaodong Chen , Yifan Xu , Chao Wang , Wencong Guo , Yancheng Song , Bing Chen

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引用次数: 0

Abstract

Background

Life’s Crucial 9 (LC9) is a composite cardiovascular health score comprising nine modifiable factors. This study examines the relationship between LC9 scores and stroke prevalence in US adults.

Methods

This study conducted a cross-sectional analysis of National Health and Nutrition Examination Survey data from 2005 to 2018. To facilitate analysis, LC9 values were separated into four quartiles. The relationship between LC9 scores and the prevalence of stroke was evaluated using subgroup analysis, restricted cubic spline (RCS) modeling, and weighted multivariable logistic regression.

Results

Among 19 207 participants with an average LC9 score of 70.70 ± 0.22, the overall stroke prevalence was 2.87 %. Each one-point increase in LC9 score was associated with a 4.7 % reduction in stroke odds (95 % CI 0.943–0.963; p < 0.001). Compared with the lowest LC9 quartile (Q1), individuals in the highest quartile (Q4) had a 72.6 % lower stroke prevalence (95 % CI 0.169–0.446; p < 0.001). Stratified analyses and interaction assessments indicated that the inverse association remained consistent across age, sex, BMI, diabetes, and hypertension categories, with no significant interactions observed. Furthermore, curve fitting analysis identified a linear correlation between LC9 scores and the risk of stroke.

Conclusions

Our findings indicated that higher LC9 scores were associated with a reduced likelihood of stroke. Preserving a favorable LC9 score may serve as a potential strategy for stroke prevention. To substantiate these observations and establish clinically applicable LC9 thresholds, additional large-scale prospective studies with prolonged follow-up are needed.

查看原文本刊更多论文

生命关键因素与中风之间的联系：NHANES 2005-2018的结果。

背景：Life's critical 9 （LC9）是一个由9个可修改因素组成的心血管健康综合评分。本研究探讨了美国成人LC9评分与卒中患病率之间的关系。方法：对2005 - 2018年全国健康与营养调查数据进行横断面分析。为了便于分析，LC9值被分成4个四分位数。采用亚组分析、限制性三次样条（RCS）模型和加权多变量logistic回归评估LC9评分与卒中患病率之间的关系。结果：19 207名参与者的平均LC9得分为70.70±0.22，卒中总患病率为2.87%。LC9评分每增加1分，卒中几率降低4.7% （95% CI 0.943-0.963; p < 0.001）。与最低LC9四分位数（Q1）相比，最高四分位数（Q4）的个体卒中患病率降低72.6% （95% CI 0.169-0.446; p < 0.001）。分层分析和相互作用评估表明，在年龄、性别、BMI、糖尿病和高血压类别中，负相关保持一致，没有观察到显著的相互作用。此外，曲线拟合分析发现LC9评分与卒中风险之间存在线性相关。结论：我们的研究结果表明，较高的LC9评分与卒中可能性降低有关。保持有利的LC9评分可能是预防脑卒中的潜在策略。为了证实这些观察结果并建立临床适用的LC9阈值，需要更多的大规模前瞻性研究和长时间随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.