Serum Creatinine and Cystatin C–Derived Indices Suggesting Future Deterioration in Muscular Function, Physical Performance, and Frailty Status Among Community-Dwelling Older Adults

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition Pub Date : 2026-03-01 Epub Date: 2025-10-01 DOI:10.1053/j.jrn.2025.06.010

Ryota Matsuzawa , Koutatsu Nagai , Kanae Takahashi , Takara Mori , Masaaki Onishi , Shotaro Tsuji , Kana Hashimoto , Kayoko Tamaki , Yosuke Wada , Hiroshi Kusunoki , Yasuyuki Nagasawa , Ken Shinmura

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引用次数: 0

Abstract

Objectives

Serum biomarkers, particularly serum creatinine and cystatin C, have garnered increased attention as a potential method for predicting future declines in muscle strength. Nevertheless, there is currently a dearth of research in this area. We evaluated the association of serum creatinine and cystatin C-derived indices with the subsequent decline in lower extremity muscle strength among community-dwelling older adults.

Design

A prospective observational study.

Setting and Subjects

Community-dwelling older individuals (aged ≥65 years) residing in the Sasayama-Tamba area of Japan.

Predictor

Five indices based on serum creatinine, and cystatin C, including the total body muscle mass index (TBMM), were computed.

Main outcome

Changes in muscular function including isometric knee extensor strength and handgrip strength, physical performance, and frailty status, underwent assessments at baseline and 2 years.

Results

The final dataset comprised 528 community-dwelling older adults (72 [68, 76] years, 65.7% women). The median change and the proportion of individuals experiencing a significant decline in isometric knee extensor strength over a 2-year period were −37.4 N and 40.2%, respectively. total body muscle mass index showed significant associations with the subsequent decline in isometric knee extensor strength, handgrip strength, and frailty status.

Conclusions

This study demonstrates the association between serum creatinine and cystatin C-derived index, total body muscle mass index, and the subsequent decline in lower extremity muscle strength among older adults. Utilizing markers derived from serum creatinine and cystatin C enables prompt assessment of the need for proactive measures and may facilitate initiating these interventions at a suitable juncture for older individuals.

查看原文本刊更多论文

血清肌酐和胱抑素c衍生指标提示社区居住老年人肌肉功能、身体表现和虚弱状态的未来恶化。

目的：血清生物标志物，特别是血清肌酐和胱抑素C，作为预测未来肌肉力量下降的潜在方法，已经引起了越来越多的关注。然而，目前在这方面的研究还很缺乏。我们评估了在社区居住的老年人中血清肌酐和胱抑素c衍生指数与随后下肢肌力下降的关系。设计：前瞻性观察研究。环境和对象：居住在日本笹山-坦巴地区的社区老年人（年龄≥65岁）。预测指标：计算基于血清肌酐和胱抑素C的5项指标，包括全身肌肉质量指数（TBMM）。主要结局：肌肉功能的变化，包括等距膝关节伸肌力量和握力、身体表现和虚弱状态，在基线和两年时进行评估。结果：最终的数据集包括528名社区居住的老年人（72[68,76]岁，65.7%为女性）。在2年的时间里，中位变化和经历等距膝关节伸肌力量显著下降的个体比例分别为-37.4N和40.2%。TBMM与随后的等长膝关节伸肌力量、握力和虚弱状态的下降有显著关联。结论：本研究证实了血清肌酐和胱抑素c衍生指数TBMM以及老年人下肢肌力下降之间的关联。利用血清肌酐和胱抑素C的标志物，可以及时评估是否需要采取积极措施，并有助于在适当的时机对老年人启动这些干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Nutrition 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

12.50%

发文量

146

审稿时长

6.7 weeks

期刊介绍： The Journal of Renal Nutrition is devoted exclusively to renal nutrition science and renal dietetics. Its content is appropriate for nutritionists, physicians and researchers working in nephrology. Each issue contains a state-of-the-art review, original research, articles on the clinical management and education of patients, a current literature review, and nutritional analysis of food products that have clinical relevance.