Unraveling the interplay between RAS axes and NOX signaling in fibroblasts during cardiac fibrosis.

IF 3.7 2区生物学 Q3 CELL BIOLOGY

Molecular and Cellular Biochemistry Pub Date : 2025-10-04 DOI:10.1007/s11010-025-05400-1

Gauri Chaturvedi, Anita Chauhan, Nandini Dubey, Sandeep Seth, Jagriti Bhatia, Subhash Chandra Yadav, Harlokesh Narayan Yadav

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引用次数: 0

Abstract

Cardiac fibrosis results from cardiovascular diseases (CVDs) and is characterized by excessive extracellular matrix (ECM) accumulation, particularly collagen, leading to cardiac dysfunction. Despite the availability of treatments for CVDs, no targeted therapies are available to prevent disease progression to irreversible stages. Further research is needed to explore the pathways and signaling molecules involved in this progression. The renin-angiotensin system (RAS) plays a significant role, with pharmacological agents targeting its harmful axis, i.e., Angiotensin-converting enzyme (ACE)/Angiotensin II (Ang II)/Angiotensin 1 receptor (AT1R) axis, while an antagonistic axis, ACE2/Angiotensin 1-7 (Ang 1-7)/mitochondrial assembly receptor (MasR) axis offers cardioprotective effects. Reactive oxygen species (ROS) also contribute to CVDs, with NADPH oxidases (NOXes) being key inducers of ROS. NOX1, NOX2, NOX4, and NOX5 are upregulated in pathological conditions, exacerbating the disease. This review focuses on the mechanisms by which the ACE/Ang II/AT1R and ACE2/Ang 1-7/MasR axes regulate NOX activity, aiming to enhance our understanding of future targeted therapies.

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揭示心脏纤维化过程中成纤维细胞中RAS轴和NOX信号之间的相互作用。

心脏纤维化是由心血管疾病（cvd）引起的，其特征是细胞外基质（ECM）积聚过多，尤其是胶原蛋白，导致心功能障碍。尽管有心血管疾病的治疗方法，但没有靶向治疗方法可以预防疾病进展到不可逆转的阶段。需要进一步的研究来探索参与这一过程的途径和信号分子。肾素-血管紧张素系统（RAS）发挥着重要作用，药物靶向其有害轴，即血管紧张素转换酶(ACE)/血管紧张素II (Ang II)/血管紧张素1受体（AT1R）轴，而拮抗轴，ACE2/血管紧张素1-7 (Ang 1-7)/线粒体组装受体（MasR）轴具有心脏保护作用。活性氧（ROS）也参与cvd的发生，其中NADPH氧化酶（NOXes）是ROS的关键诱导剂。病理状态下NOX1、NOX2、NOX4和NOX5上调，加重疾病。本文综述了ACE/Ang II/AT1R和ACE2/Ang 1-7/MasR轴调控NOX活性的机制，旨在提高我们对未来靶向治疗的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.