Cytokine expression profile in the human brain of older adults.

IF 10.1 1区医学 Q1 IMMUNOLOGY

Journal of Neuroinflammation Pub Date : 2025-10-03 DOI:10.1186/s12974-025-03552-x

Juliana Beker Godoy, Ricardo A Vialle, Loren Dos Santos, Roberto T Raittz, Yanling Wang, Vilas Menon, Philip L De Jager, Julie A Schneider, Shinya Tasaki, David A Bennett, Dieval Guizelini, Katia de Paiva Lopes

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引用次数: 0

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative condition linked to chronic neuroinflammation. This study investigates the cytokine gene expression profile in cortical tissue samples from elderly individuals with and without AD to identify potential biomarkers and enhance our understanding of disease pathogenesis. Utilizing high-depth RNA sequencing data, we identified a set of cytokines whose expression significantly associated with different aspects of the AD phenotype, including measures of neurofibrillary tangles, amyloid-β deposition, and a person-specific rate of cognitive decline. Single-nucleus transcriptomics data facilitated the identification of specific cell types, such as microglia and astrocytes, that significantly contribute to the inflammatory response in AD. Additionally, we observed a correlation between the expression of certain cytokines and genetic risk for the disease. Our findings indicate that cytokine-mediated neuroinflammation may play an important role in neurodegeneration and that modulating the immune response may offer a promising strategy for developing new therapies.

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老年人大脑细胞因子表达谱。

阿尔茨海默病（AD）是一种复杂的神经退行性疾病，与慢性神经炎症有关。本研究研究了老年AD患者和非老年AD患者皮质组织样本中的细胞因子基因表达谱，以确定潜在的生物标志物并增强我们对疾病发病机制的理解。利用高深度RNA测序数据，我们确定了一组细胞因子，其表达与阿尔茨海默病表型的不同方面显著相关，包括神经原纤维缠结、淀粉样蛋白-β沉积和个体特异性认知衰退率。单核转录组学数据有助于识别特定的细胞类型，如小胶质细胞和星形胶质细胞，它们在AD的炎症反应中起着重要作用。此外，我们观察到某些细胞因子的表达与该疾病的遗传风险之间存在相关性。我们的研究结果表明，细胞因子介导的神经炎症可能在神经退行性变中发挥重要作用，调节免疫反应可能为开发新疗法提供有希望的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroinflammation 医学-神经科学

CiteScore

15.90

自引率

3.20%

发文量

276

审稿时长

1 months

期刊介绍： The Journal of Neuroinflammation is a peer-reviewed, open access publication that emphasizes the interaction between the immune system, particularly the innate immune system, and the nervous system. It covers various aspects, including the involvement of CNS immune mediators like microglia and astrocytes, the cytokines and chemokines they produce, and the influence of peripheral neuro-immune interactions, T cells, monocytes, complement proteins, acute phase proteins, oxidative injury, and related molecular processes. Neuroinflammation is a rapidly expanding field that has significantly enhanced our knowledge of chronic neurological diseases. It attracts researchers from diverse disciplines such as pathology, biochemistry, molecular biology, genetics, clinical medicine, and epidemiology. Substantial contributions to this field have been made through studies involving populations, patients, postmortem tissues, animal models, and in vitro systems. The Journal of Neuroinflammation consolidates research that centers around common pathogenic processes. It serves as a platform for integrative reviews and commentaries in this field.