3D T1 turbo spin echo improves detection of gadolinium-enhancing multiple-sclerosis lesions.

IF 4.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-10-03 DOI:10.1186/s13244-025-02093-4

Pablo Naval-Baudin, William F Bermúdez Bravo, Vanessa I Pineda-Borja, Pablo Arroyo-Pereiro, Ignacio Martínez-Zalacaín, Lucía Romero-Pinel, Paloma Mora, Nahum Calvo, Antonio Martínez-Yélamos, Sergio Martínez-Yélamos, Mònica Cos, Albert Pons-Escoda, Carles Majós

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引用次数: 0

Abstract

Objectives: To compare the performance of 3D T1 turbo spin echo (3DT1TSE) and 3D T1 turbo field echo (3DT1TFE) MRI in detecting gadolinium-enhancing lesions in multiple sclerosis (MS).

Materials and methods: We retrospectively analyzed 255 3-T MRIs from MS patients, each including post-contrast 3DT1TSE and 3DT1TFE sequences. Two blinded readers independently assessed enhancing lesions per sequence. A consensus review, incorporating longitudinal imaging and additional sequences, served as the reference standard.

Results: The consensus identified 70 enhancing lesions in 31 patients. All 70 were visible on 3DT1TSE, while 64 (91%) were detectable on 3DT1TFE. Reader sensitivity was higher for 3DT1TSE (84% and 90%) than 3DT1TFE (45% and 40%) (p < 0.01). Inter-reader agreement was excellent for 3DT1TSE (ICC = 0.90) and moderate for 3DT1TFE (intraclass correlation coefficient = 0.69). Although false positives were more common with 3DT1TSE, they were readily excluded during consensus reading. In six patients, enhancing lesions were detected only on 3DT1TSE, with treatment escalation in two.

Conclusion: 3DT1TSE outperformed 3DT1TFE in sensitivity and reader agreement for enhancing lesion detection in MS. Incorporating 3DT1TSE into standard MRI protocols may improve disease activity assessment and clinical decision-making.

Critical relevance statement: Replacing 3D gradient-echo with post-contrast 3D T1 turbo spin-echo brain MRI greatly improves the detection of gadolinium-enhancing multiple-sclerosis lesions, boosting diagnostic sensitivity and reader agreement and directly influencing treatment-escalation decisions in routine practice.

Key points: Detecting and enhancing MS lesions is limited by standard 3D T1 turbo field echo (3DT1TFE) MRI. 3D T1 turbo spin echo detects significantly more gadolinium-enhancing MS lesions than conventional 3DT1TFE. Greater lesion detection allows more precise activity assessment and optimal treatment management.

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3D T1涡轮自旋回波提高钆增强多发性硬化病变的检出。

目的：比较3DT1涡轮自旋回波（3DT1TSE）与3DT1涡轮场回波（3DT1TFE） MRI对多发性硬化症（MS）钆增强病变的检测效果。材料和方法：我们回顾性分析了255例MS患者的3-T mri，包括对比后3DT1TSE和3DT1TFE序列。两名盲法读者独立评估每个序列的强化病变。结合纵向成像和附加序列的共识审查，作为参考标准。结果：在31例患者中发现70个强化病灶。所有70例在3DT1TSE上可见，而64例（91%）在3DT1TFE上可见。3DT1TSE的灵敏度（84%和90%）高于3DT1TFE(45%和40%)(p结论：3DT1TSE在增强ms病变检测的敏感性和读者一致性方面优于3DT1TFE，将3DT1TSE纳入标准MRI方案可改善疾病活动性评估和临床决策。关键相关性声明：用对比后的3D T1涡轮自旋回波脑MRI代替3D梯度回波，极大地提高了钆增强多发性硬化症病变的检测，提高了诊断敏感性和读者的共识，并直接影响了常规实践中治疗升级的决定。重点：标准的3DT1涡轮场回波（3DT1TFE） MRI检测和增强MS病变是有限的。与传统3DT1TFE相比，3DT1涡轮自旋回波检测到更多钆增强的MS病变。更大的病变检测允许更精确的活动评估和最佳治疗管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.