Intake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: a prospective analysis in the EPIC cohort.

IF 6.8 1区医学 Q1 ONCOLOGY

British Journal of Cancer Pub Date : 2025-10-04 DOI:10.1038/s41416-025-03228-6

Enrique Almanza-Aguilera, David Guananga-Álvarez, Yolanda Benavente, Alexandra Nieters, Caroline Besson, Fatemeh Saberi Hosnijeh, Cecilie Kyrø, Nicola P Bondonno, Christina C Dahm, Elisabete Weiderpass, Therese Truong, Mariem Louati-Hajji, Xuan Ren, Verena Katzke, Matthias B Schulze, Fabrizio Pasanisi, Claudia Vener, Giovanna Masala, Maria Teresa Giraudo, Rosario Tumino, Amaia Aizpurua, Maria-Jose Sánchez, José María Huerta, Marcela Guevara, Cristina Lasheras, Paolo Vineis, Roel Vermeulen, Raul Zamora-Ros, Delphine Casabonne

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引用次数: 0

Abstract

Background: Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited.

Methods: We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models.

Results: During a mean 14-year follow-up (time frame: from 1990-1994 to 2008-2013), 2394 incident lymphoma cases were diagnosed from a total of 367,463 individuals. No significant associations were observed between total intakes of (poly)phenols, flavonoids, and phenolic acids and overall lymphoma risk. Total (poly)phenols, phenolic acid and hydroxycinnamic acid intakes were positively associated with Hodgkin lymphoma (HL) risk [HR_log2 = 2.56 (95% confidence interval: 1.27-5.16); 1.81 (1.14-2.87); and 1.48 (1.03-2.12), respectively]. Conversely, isoflavone intakes was inversely associated with risk of overall lymphoma [HR_log2 = 0.96 (0.93-0.99)], and non-Hodgkin lymphoma [HR_log2 = 0.95 (0.92-0.99)] and mature B-cell lymphoma [HR_log2 = 0.96 (0.92-0.99)], and flavone intakes with risk of multiple myeloma/plasma cell neoplasm [HR_log2 = 0.75 (0.60-0.95)].

Conclusions: Our findings suggest that isoflavone intakes may reduce the risk of overall lymphoma and specific lymphoma subtypes, while phenolic acids, particularly hydroxycinnamic acids might increase the risk of HL.

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摄入总、类别和亚类别（多）酚与淋巴样肿瘤的风险：EPIC队列的前瞻性分析

背景：关于（多）酚摄入在淋巴瘤发展中的潜在作用的现有流行病学证据是有限的。方法：我们使用多变量校正Cox比例风险模型，研究了（多）酚的总类别、单个类别和亚类别的摄入与淋巴瘤风险之间的关系，包括EPIC队列中主要的常见亚型。结果：在平均14年的随访期间（时间框架：1990-1994年至2008-2013年），共367,463例患者中诊断出2394例淋巴瘤。（多）酚类、类黄酮和酚酸的总摄入量与总体淋巴瘤风险之间没有显著关联。总（多）酚、酚酸和羟基肉桂酸摄入量与霍奇金淋巴瘤（HL）风险呈正相关[HRlog2 = 2.56(95%可信区间：1.27-5.16)；1.81 (1.14 - -2.87);和1.48(1.03-2.12)]。相反，异黄酮摄入量与整体淋巴瘤[HRlog2 = 0.96(0.93-0.99)]、非霍奇金淋巴瘤[HRlog2 = 0.95(0.92-0.99)]和成熟b细胞淋巴瘤[HRlog2 = 0.96(0.92-0.99)]的风险呈负相关，而黄酮类摄入与多发性骨髓瘤/浆细胞肿瘤[HRlog2 = 0.75(0.60-0.95)]的风险呈负相关。结论：我们的研究结果表明，摄入异黄酮可降低整体淋巴瘤和特定淋巴瘤亚型的风险，而酚酸，特别是羟基肉桂酸可能增加HL的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Cancer 医学-肿瘤学

CiteScore

15.10

自引率

1.10%

发文量

383

审稿时长

6 months

期刊介绍： The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.