Association of Sedentary Behavior and Physical Activity With the Risk of Post-Transplant Diabetes Mellitus Among Living Donor Liver Transplant Recipients: A Cross-Sectional Isotemporal Substitution Analysis
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Abstract
Post-transplant diabetes mellitus (PTDM) affects long-term outcomes in liver transplant recipients (LTRs). While prolonged sedentary time and low physical activity (PA) increase diabetes risk, their association with PTDM among LTRs remains unclear. We investigated the relationship between sedentary behavior, PA, and PTDM while considering their interdependence. We analyzed data from 68 living donor LTRs at a single hospital. Participants wore an accelerometer on their waist for 7 consecutive days to measure sedentary time and PA. PTDM was identified from medical records, and its association with sedentary time was assessed using logistic regression. Isotemporal substitution analysis estimated the effect of substituting sedentary time with PA. The participants’ mean age was 63.4 ± 10.5 years, with a mean time since transplant of 9.0 ± 6.7 years. PTDM was present in 54% of participants, and the odds ratio for PTDM associated with ≥8 h of sedentary time was 1.60 (95% confidence interval [CI], 1.15–1.78, p = 0.015). Replacing 30 min of sedentary time with light-intensity PA lowered the odds to 0.81 (95% CI, 0.70–0.92, p = 0.001), whereas replacing it with moderate-to-vigorous PA reduced the odds to 0.28 (95% CI, 0.09–0.69, p = 0.002). Reducing sedentary time and increasing PA may contribute to the prevention of PTDM in LTRs.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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