Sacha Pérocheau Arnaud, Christian Saadé Abou Jaoudé, Sandra Olivero, Patrick Navard, Alice Mija, Veronique Michelet, Veronique Mondain
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Abstract
A simple and efficient strategy was developed for the identification of material devices’ polymers and the extraction of the additives contained within. In this study, the focus is put on the presence of phthalate esters in French medical devices, mainly on diethylhexyl phthalate (DEHP), being reported as toxic, endocrine disruptor plasticisers. Their presence was investigated across seven standard medical devices, especially concerning newborn exposure, and compared with results obtained in similar materials from the past decades. Only traces of DEHP, below the limit of quantification (< 6 ppm) were detected in one of the samples by GC–MS using a standard for identification and quantification. This study shows that phthalates’ presence in medical devices used in French hospitals has been greatly diminished, to the benefit of healthier hospital environments.
期刊介绍：
Separation sciences, in all their various forms such as chromatography, field-flow fractionation, and electrophoresis, provide some of the most powerful techniques in analytical chemistry and are applied within a number of important application areas, including archaeology, biotechnology, clinical, environmental, food, medical, petroleum, pharmaceutical, polymer and biopolymer research. Beyond serving analytical purposes, separation techniques are also used for preparative and process-scale applications. The scope and power of separation sciences is significantly extended by combination with spectroscopic detection methods (e.g., laser-based approaches, nuclear-magnetic resonance, Raman, chemiluminescence) and particularly, mass spectrometry, to create hyphenated techniques. In addition to exciting new developments in chromatography, such as ultra high-pressure systems, multidimensional separations, and high-temperature approaches, there have also been great advances in hybrid methods combining chromatography and electro-based separations, especially on the micro- and nanoscale. Integrated biological procedures (e.g., enzymatic, immunological, receptor-based assays) can also be part of the overall analytical process.
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