An acetabular component made from highly cross-linked polyethylene enriched with vitamin E: 10-year clinical results and wear rates

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2025-08-23 DOI:10.1016/j.jor.2025.08.021

J.H.J. van Erp , H. Erisen , T.E. Snijders , J.E.J. Bekkers , A. de Gast

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引用次数: 0

Abstract

Background

A common reason for total hip replacement revisions worldwide is aseptic loosening. To address this issue, a new acetabular component was developed with vitamin E incorporated into its irradiated highly cross-linker polyethylene (HXLPE). Vitamin E might be capable of reducing polyethylene wear by stabilizing free radicals in HLXPE, thus preventing oxidation and enhancing wear resistance. This study aimed to evaluate a vitamin E-enriched HXLPE acetabular component over a 10-year period to assess its impact on wear and osteolysis.

Methods

A total of 112 patients underwent total hip replacement with a vitamin E blended HXLPE acetabular component. Various assessments were conducted, such as pain scores, patient satisfaction, Harris Hip Score (HHS), amount of femoral head penetration, and radiological parameters.

Results

84 of 112 Patients (75 %) completed the 10-year follow-up. At the 10-year follow-up, patients reported high satisfaction (VAS score: 8.9) and high HHS (93.3). No revision procedure was performed due to instability, two patients underwent revision surgery due to a deep infection, and one patient required revision surgery due to a periprosthetic fracture. The survival rate for aseptic loosening was 100 %, with a 95.5 % rate to revision. The average rate of the femoral head penetration was 0.028 mm/year (SD: 0.011), including a 0.252 mm mean total head penetration (SD: 0.274). Several radiological parameter analyses had been conducted and revealed no abnormalities, equal to the 6-year follow-up.

Conclusion

This 10-year follow-up study demonstrated good clinical outcomes of the vitamin E enriched HXLPE acetabular cup with a low wear-rate. These findings suggest that incorporating vitamin E can potentially improve the effectiveness and durability of hip replacement procedures. However, further research comparing it to other polyethylene is required to determine potential clinical superiority.

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由富含维生素E的高交联聚乙烯制成的髋臼组件：10年临床结果和磨损率

世界范围内全髋关节置换术翻修的一个常见原因是无菌性松动。为了解决这个问题，开发了一种新的髋臼组件，将维生素E纳入其辐照的高交联聚乙烯（HXLPE）中。维生素E可能通过稳定HLXPE中的自由基来减少聚乙烯磨损，从而防止氧化，提高耐磨性。本研究旨在对一种富含维生素e的HXLPE髋臼组件进行为期10年的评估，以评估其对磨损和骨溶解的影响。方法112例患者行维生素E混合HXLPE髋臼假体全髋关节置换术。进行了各种评估，如疼痛评分、患者满意度、Harris髋关节评分（HHS）、股骨头穿透量和放射学参数。结果112例患者中有84例（75%）完成了10年随访。在10年随访中，患者满意度高（VAS评分8.9），HHS评分高（93.3）。未因不稳定进行翻修手术，2例患者因深部感染进行翻修手术，1例患者因假体周围骨折需要翻修手术。无菌性松动的生存率为100%，翻修的生存率为95.5%。股骨头平均穿透率为0.028 mm/年（SD: 0.011），其中股骨头平均总穿透率为0.252 mm （SD: 0.274）。进行了几次放射学参数分析，并没有发现异常，相当于6年的随访。结论通过10年的随访研究表明，富含维生素E的HXLPE髋臼杯具有良好的临床效果，磨损率低。这些发现表明，加入维生素E可以潜在地提高髋关节置换术的有效性和持久性。然而，需要进一步的研究将其与其他聚乙烯进行比较，以确定其潜在的临床优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.