Hot-spot empowered gold nanoparticles for theranostics in breast cancer.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-30 eCollection Date: 2025-01-01 DOI:10.7150/thno.119678
Meng Tian, Shiqi Hu, Wen Sun, Ying Hu, Xingyi Ma
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引用次数: 0

Abstract

Breast cancer, being the most prevalent malignant tumor among women, confronts severe challenges in its early detection and precise treatment. Traditional diagnostic approaches have drawbacks in terms of sensitivity and specificity, and are invasive, thereby making it arduous to satisfy practical demands. Nanomedicine has introduced novel diagnostic and therapeutic modalities for breast cancer, particularly gold nanoparticles (AuNPs), which have been utilized on account of their distinctive optical and physicochemical attributes. Hot-spot empowered AuNPs have rapidly emerged and demonstrated significant potential in the diagnosis and treatment of breast cancer. From a technical standpoint, the design and synthesis of AuNPs hot-spot are constantly evolving, ranging from the control of number to the control of structure and efficient control of hot-spot utilizations, establishing a development model of "number-structure-efficient utilization". Hot-spot empowered AuNPs are extensively employed in diagnosis and therapy, facilitating targeted drug delivery, photothermal and photodynamic therapy, and multimodal integration therapy, and also achieving the function of theranostics in an innovative manner. We have deliberated on the challenges and future development prospects of precision medicine for the diagnosis of early breast cancer and individualized treatment.

热点强化金纳米颗粒用于乳腺癌治疗。
乳腺癌是女性最常见的恶性肿瘤,在早期发现和精准治疗方面面临着严峻的挑战。传统的诊断方法在敏感性和特异性方面存在不足,且具有侵入性,难以满足实际需求。纳米医学已经为乳腺癌引入了新的诊断和治疗方式,特别是金纳米颗粒(AuNPs),由于其独特的光学和物理化学特性而被利用。热点授权aunp迅速出现,并在乳腺癌的诊断和治疗中显示出巨大的潜力。从技术角度看,AuNPs热点的设计和综合在不断发展,从数量控制到结构控制和热点利用的高效控制,建立了“数量-结构-高效利用”的发展模式。热点授权aunp广泛应用于诊断和治疗,促进靶向给药、光热和光动力治疗、多模式整合治疗,并以创新的方式实现治疗学的功能。我们讨论了精准医学在早期乳腺癌诊断和个体化治疗方面面临的挑战和未来发展前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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