Dissecting Tertiary Lymphoid Structures in Cancer: Maturation, Localization and Density.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-30 eCollection Date: 2025-01-01 DOI:10.7150/thno.113940
Guang-Liang Su, Meng-Jie Zhang, Hao Li, Zhi-Jun Sun
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引用次数: 0

Abstract

Tertiary lymphoid structures (TLSs) refer to ectopic lymphoid aggregates that form in non-lymphoid tissues at sites of chronic inflammation including cancers. TLSs have been recognized as significant predictors of the efficacy of immune checkpoint blockade (ICB) therapies and have the potential to elicit robust anti-tumor immune response. However, recent studies have revealed substantial heterogeneity in TLSs across different individuals and cancer types, which directly impacts the effectiveness of anti-tumor immunity. Concretely, the maturation status, localization, and density of TLSs profoundly influence the dynamic interactions among immune cells within these structures, potentially leading to adverse effects. This review provides an in-depth exploration of how the heterogeneity of TLSs influences cellular composition and immune dynamics, with the objective of influencing the efficacy of ICB therapies and modulating prognostic prediction accuracy. Additionally, the potential of combining TLSs with other biomarkers for predicting anti-tumor immunity outcomes is further investigated, alongside the introduction of advanced technologies for evaluating TLS heterogeneity. Collectively, these analyses aim to advance the understanding of TLS heterogeneity and facilitate its translation into clinical and translational medicine applications.

肿瘤的解剖三级淋巴结构:成熟、定位和密度。
三级淋巴样结构(TLSs)是指在慢性炎症(包括癌症)部位的非淋巴样组织中形成的异位淋巴样聚集体。TLSs已被认为是免疫检查点阻断(ICB)疗法疗效的重要预测因子,并有可能引发强大的抗肿瘤免疫反应。然而,最近的研究表明,不同个体和不同癌症类型的TLSs存在很大的异质性,这直接影响了抗肿瘤免疫的有效性。具体而言,TLSs的成熟状态、定位和密度深刻影响这些结构内免疫细胞之间的动态相互作用,可能导致不良反应。本综述深入探讨了TLSs的异质性如何影响细胞组成和免疫动力学,目的是影响ICB治疗的疗效和调节预后预测的准确性。此外,研究人员还进一步研究了TLS与其他生物标志物联合预测抗肿瘤免疫结果的潜力,并引入了评估TLS异质性的先进技术。总的来说,这些分析旨在促进对TLS异质性的理解,并促进其在临床和转化医学中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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