{"title":"Human Stem Cell-Based Embryo Model Research: Ethics and Regulations.","authors":"Chie Kobayashi, Shu Ishida, Tsutomu Sawai","doi":"10.1007/7651_2025_668","DOIUrl":null,"url":null,"abstract":"<p><p>Given rapid advances in the life sciences, stem cell-based embryo models (SCBEMs) call for careful ethical and regulatory consideration. As with similar research related to human embryos and reproduction, SCBEMs raise important normative questions. In this chapter, we survey these questions, outline possible answers, and discuss their implications for global regulatory development. We also map major ethical issues related to SCBEM research, identify areas in need of further debate, and examine the governance frameworks required for responsible progress. We conclude with recommendations to guide SCBEM research so that it advances scientific innovation while protecting the public interest. In particular, we highlight the importance of careful planning, transparent communication, inclusive dialogue, robust governance, and ongoing empirical inquiry. Taken together, these measures can help ensure that SCBEM research proceeds responsibly, remains ethically sound, and earns public trust.</p>","PeriodicalId":18490,"journal":{"name":"Methods in molecular biology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Methods in molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/7651_2025_668","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Given rapid advances in the life sciences, stem cell-based embryo models (SCBEMs) call for careful ethical and regulatory consideration. As with similar research related to human embryos and reproduction, SCBEMs raise important normative questions. In this chapter, we survey these questions, outline possible answers, and discuss their implications for global regulatory development. We also map major ethical issues related to SCBEM research, identify areas in need of further debate, and examine the governance frameworks required for responsible progress. We conclude with recommendations to guide SCBEM research so that it advances scientific innovation while protecting the public interest. In particular, we highlight the importance of careful planning, transparent communication, inclusive dialogue, robust governance, and ongoing empirical inquiry. Taken together, these measures can help ensure that SCBEM research proceeds responsibly, remains ethically sound, and earns public trust.
期刊介绍：
For over 20 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by-step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
