The role of LncRNA SNHG3 in human cancers.

Abstract

An essential category of non-protein-coding RNA molecules, known as long noncoding RNAs (lncRNAs), are naturally occurring RNA sequences exceeding 200 nucleotides in length. Accumulating evidence has unveiled the significant involvement of lncRNAs in various cancers, where they are known to be a key factor for tumors' statement changing, e.g., modulating proliferative, apoptotic, migratory and chemotherapy resistance in cells. In addition, lncRNAs are also regarded as potential diagnostic and prognostic tumor biomarkers. Studies have suggested that lncRNAs modulate biological processes by regulating linear RNA transcription and protein production. A recently discovered long non-coding RNA, SNHG3, is identified to have associations with cancer, which displays atypical expression patterns and functions as an oncogene in various cancers. Additionally, SNHG3 has been demonstrated to hold promise as a diagnostic biomarker and a tool for prognostic assessment in cancer patients. This review summarizes current knowledge about SNHG3's expression, functional roles, molecular mechanisms, and implications for diagnosis and prognosis in human cancers.