Disulfidptosis mechanisms and therapeutic implications in cancer metabolic reprogramming and future perspectives.

Abstract

Regulatory cell death exhibits distinctive advantages in cancer therapy. Among such mechanisms, disulfidptosis effectively inhibits tumor growth by inducing disulfide bond stress and subsequent rupture under particular conditions, thus demonstrating substantial potential for cancer treatment. Genes associated with disulfidptosis contribute to the survival and proliferation of various cancer cell types. They significantly impact the tumor microenvironment (TME) by modulating cancer's metabolic reprogramming and antioxidant response, achieving anti-tumor effects. This review explores the recently identified regulatory cell death mechanism, disulfidptosis, through an examination of its mechanisms, the relationship between relevant genes and cancer, analyses of the TME, and the prospects of emerging therapeutics, offering fresh insights for disulfidptosis research in oncology.