A Pilot Study of Porcine Acellular Bladder Matrix Filling in the Treatment of Anal Fistulas: A Single-Center Cohort Study.

IF 1.6 4区医学 Q3 SURGERY

ANZ Journal of Surgery Pub Date : 2025-10-03 DOI:10.1111/ans.70342

Xiang Ma, Weisong Xue, Zuolin Zhou, Qiong He, Feng Yang, Ningchao Du, Jun Sun, Huiwen Ning, NiNi Liu, Ying Luo, Jian Cai

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引用次数: 0

Abstract

Objective: This study aimed to preliminarily assess the effectiveness of a novel biomaterial, porcine acellular bladder matrix (PABM), in filling fistula tracts.

Summary of background data: Anal fistula plugs (AFPs) made from biomaterials are designed to fill fistulas, promote tissue healing, and prevent anal sphincter damage caused by conventional surgeries.

Methods: This single-center cross-sectional study evaluated PABM-AFP treatment for anal fistulas between May 2023 and May 2024. Twenty-eight patients diagnosed with anal fistulas underwent PABM-AFP filling, with follow-up conducted for 6-12 months postoperatively.

Results: The overall success rate was 89.3%, with an efficacy rate of 90.6% for all treated fistulas. Of the three patients who experienced treatment failure, two recovered after receiving thread-ligating treatment, and the remaining patient who had Crohn's disease experienced partial healing. The mean healing time was 5 weeks, and the average follow-up duration was 7 months. No adverse complications were reported.

Conclusions: PABM-AFP is a promising, safe, and effective treatment option for anal fistulas. This study provides valuable preliminary data to support the clinical use of PABM-AFP.

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猪脱细胞膀胱基质填充治疗肛瘘的初步研究：一项单中心队列研究。

目的：初步评价新型生物材料猪脱细胞膀胱基质（PABM）填充瘘管束的效果。背景资料概述：生物材料制成的肛瘘塞（AFPs）用于填充瘘管，促进组织愈合，防止常规手术引起的肛门括约肌损伤。方法：本单中心横断面研究评估了2023年5月至2024年5月间PABM-AFP治疗肛瘘的效果。28例确诊为肛瘘的患者行PABM-AFP填充术，术后随访6-12个月。结果：总成功率89.3%，所有治疗的瘘有效率为90.6%。在治疗失败的三名患者中，两名患者在接受结扎治疗后康复，其余患有克罗恩病的患者部分痊愈。平均愈合时间5周，平均随访时间7个月。无不良并发症报道。结论：PABM-AFP治疗肛瘘是一种安全有效的治疗方法。本研究为支持PABM-AFP的临床应用提供了有价值的初步数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ANZ Journal of Surgery 医学-外科

CiteScore

2.50

自引率

11.80%

发文量

720

审稿时长

2 months

期刊介绍： ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.