Autoimmune Myasthenia Gravis.

Q1 Medicine

CONTINUUM Lifelong Learning in Neurology Pub Date : 2025-10-01 Epub Date: 2025-10-02 DOI:10.1212/cont.0000000000001612

Vern C Juel

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引用次数: 0

Abstract

Objective: This article reviews the diagnosis and management of autoimmune myasthenia gravis (MG), encompassing epidemiology, clinical features including disease heterogeneity, pathophysiology, and therapeutic approaches.

Latest developments: Recent advances in MG pathophysiology and clinical outcome measures have catalyzed the development of novel therapies, including complement and neonatal Fc receptor inhibitors, which target specific components of the autoimmune attack on the muscle endplate.

Essential points: Patients with MG exhibit fluctuating muscle weakness. Diagnosis is confirmed by acetylcholine receptor or muscle-specific kinase (MuSK) antibodies, electrodiagnostic testing, or both. Management involves tailored combinations of therapies based on patient and MG-specific factors. The treatment of patients with MG with exclusively ocular weakness, thymoma, child-bearing potential, myasthenic crisis, or MG related to cancer immunotherapy has unique considerations. Prompt diagnosis and treatment are crucial to restore neuromuscular function and minimize treatment-related complications.

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自身免疫性重症肌无力

目的：本文综述了自身免疫性重症肌无力（MG）的诊断和治疗，包括流行病学、临床特征（包括疾病异质性）、病理生理学和治疗方法。最新进展：MG病理生理学和临床结果测量的最新进展促进了新疗法的发展，包括补体和新生儿Fc受体抑制剂，其靶向自身免疫攻击肌肉终板的特定成分。要点：MG患者表现为波动性肌无力。诊断是由乙酰胆碱受体或肌肉特异性激酶（MuSK）抗体，电诊断测试，或两者证实。管理包括根据患者和mg特异性因素量身定制的治疗组合。仅伴有眼无力、胸腺瘤、生育潜力、肌无力危象或与癌症免疫治疗相关的MG患者的治疗有独特的考虑。及时诊断和治疗对于恢复神经肌肉功能和减少治疗相关并发症至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CONTINUUM Lifelong Learning in Neurology Medicine-Medicine (all)

CiteScore

5.80

自引率

0.00%

发文量

175

期刊介绍： Continue your professional development on your own schedule with Continuum: Lifelong Learning in Neurology®, the American Academy of Neurology" self-study continuing medical education publication. Six times a year you"ll learn from neurology"s experts in a convenient format for home or office. Each issue includes diagnostic and treatment outlines, clinical case studies, a topic-relevant ethics case, detailed patient management problem, and a multiple-choice self-assessment examination.