Validity of a simple spillover correction for positron emission tomography measurements in the cerebrospinal fluid region.

IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Radiological Physics and Technology Pub Date : 2025-10-02 DOI:10.1007/s12194-025-00972-5

Emi Hayashi, Shin Hibino, Mitsuhito Mase

{"title":"Validity of a simple spillover correction for positron emission tomography measurements in the cerebrospinal fluid region.","authors":"Emi Hayashi, Shin Hibino, Mitsuhito Mase","doi":"10.1007/s12194-025-00972-5","DOIUrl":null,"url":null,"abstract":"Positron emission tomography (PET) measurements in the cerebrospinal fluid (CSF) region may be overestimated because of spillover artifacts from surrounding radioactivity. In this study, we proposed a simple spillover correction method (subtraction method) and evaluated its validity. A cylindrical phantom simulating brain ventricles was used to compare the subtraction method with the geometric transfer matrix (GTM) correction approach. And the subtraction method was applied to dynamic PET images of [18F]fluorodeoxyglucose (FDG), [18F]fluorodopa (FDOPA), and [11C]raclopride (RAC), and [15O]H2O (H2O). The effects of spillover correction on CSF measurements were assessed. Both methods effectively reduced spillover artifacts in the phantom study. In dynamic PET images, after spillover correction, time-activity curves for FDG, FDOPA, and RAC approached near-zero levels in the CSF, whereas H2O continued to show increasing activity over time. This approach effectively reduces artifacts and offers the advantages of simpler volume-of-interest settings and straightforward calculation procedures.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiological Physics and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12194-025-00972-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Positron emission tomography (PET) measurements in the cerebrospinal fluid (CSF) region may be overestimated because of spillover artifacts from surrounding radioactivity. In this study, we proposed a simple spillover correction method (subtraction method) and evaluated its validity. A cylindrical phantom simulating brain ventricles was used to compare the subtraction method with the geometric transfer matrix (GTM) correction approach. And the subtraction method was applied to dynamic PET images of [¹⁸F]fluorodeoxyglucose (FDG), [¹⁸F]fluorodopa (FDOPA), and [¹¹C]raclopride (RAC), and [¹⁵O]H₂O (H₂O). The effects of spillover correction on CSF measurements were assessed. Both methods effectively reduced spillover artifacts in the phantom study. In dynamic PET images, after spillover correction, time-activity curves for FDG, FDOPA, and RAC approached near-zero levels in the CSF, whereas H₂O continued to show increasing activity over time. This approach effectively reduces artifacts and offers the advantages of simpler volume-of-interest settings and straightforward calculation procedures.

查看原文本刊更多论文

脑脊液区正电子发射断层扫描测量的简单溢出校正的有效性。

正电子发射断层扫描（PET）在脑脊液（CSF）区域的测量可能被高估，因为从周围的放射性溢出的伪影。本研究提出了一种简单的溢出校正方法（减法），并对其有效性进行了评价。利用模拟脑室的圆柱形模型，比较了几何传递矩阵（GTM）校正法和减法校正法的优缺点。将减法应用于[18F]氟脱氧葡萄糖（FDG）、[18F]氟多巴（FDOPA）、[11C]氟氯pride （RAC）和[15O]H2O （H2O）的动态PET图像。评估了溢出校正对脑脊液测量的影响。这两种方法都有效地减少了假体研究中的溢出伪影。在动态PET图像中，经过外溢校正后，CSF中FDG、FDOPA和RAC的时间-活性曲线接近于零水平，而H2O的活性随着时间的推移继续增加。这种方法有效地减少了工件，并提供了更简单的兴趣量设置和直接的计算过程的优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

3.00

自引率

12.50%

发文量

期刊介绍： The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.