Biological Sex and Body Mass Index Influence the Longitudinal Evolution of Adolescent and Young Adult Magnetic Resonance Imaging-Visible Perivascular Spaces

IF 2.1 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2025-09-01 DOI:10.1016/j.pediatrneurol.2025.08.021

Erin A. Yamamoto MD , Seiji Koike MAS , Caitlyn Wong BS , Laura E. Dennis BS , Madison N. Luther BS , Avery Scatena BA , Seva Khambadkone MD, PhD , Jeffrey J. Iliff PhD , Miranda M. Lim MD, PhD , Swati R. Levendovszky PhD , Jonathan E. Elliott PhD , Giuseppe Barisano MD, PhD , Eva M. Müller-Oehring PhD , Angelica M. Morales PhD , Fiona C. Baker PhD , Bonnie J. Nagel PhD , Juan Piantino MD, MCR

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引用次数: 0

Abstract

Background

An association recently emerged between magnetic resonance imaging (MRI)-visible perivascular spaces (MV-PVS) with intracerebral solute clearance and neuroinflammation, in adults. However, it is unknown how MV-PVS change throughout adolescence and what factors influence MV-PVS volume and morphology. This study assesses the temporal evolution of MV-PVS volume in adolescents and young adults, and secondarily evaluates the relationship between MV-PVS, age, sex, and body mass index (BMI).

Methods

This analysis included a 783 participant cohort from the longitudinal multicenter National Consortium on Alcohol and Neurodevelopment in Adolescence study that involved up to 6 imaging visits spanning 5 years. Healthy adolescents aged 12-21 years at study entry with at least two MRI scans were included. The primary outcome was mean MV-PVS volume (mm³/white matter cm³).

Results

On average, males had greater MV-PVS volume at all ages compared to females. A linear mixed-effect model for MV-PVS volume was performed. Mean BMI and increases in a person's BMI were associated with increases in MV-PVS volume over time. In females only, changes in BMI correlated with MV-PVS volume. One unit increase in BMI above a person's average BMI was associated with a 0.021 mm³/cm³ increase in MV-PVS volume (P < 0.001).

Conclusions

This longitudinal study showed sex differences in MV-PVS features during adolescence and young adulthood. Importantly, we report that increases in BMI from a person's mean BMI are associated with increases in MV-PVS volume in females only. These findings suggest a potential link between MV-PVS, sex, and BMI that warrants future study.

查看原文本刊更多论文

生理性别和体重指数影响青少年和青年磁共振成像-可见血管周围空间的纵向演变。

背景：最近发现磁共振成像(MRI)-可见血管周围间隙（mv - pv）与成人脑内溶质清除和神经炎症之间存在关联。然而，mv - pv在整个青春期如何变化以及影响mv - pv体积和形态的因素尚不清楚。本研究评估了青少年和青壮年MV-PVS体积的时间演变，并评估了MV-PVS与年龄、性别和体重指数（BMI）的关系。方法：本分析纳入了783名参与者队列，这些参与者来自纵向多中心国家酒精和青少年神经发育联盟研究，涉及长达5年的6次影像学检查。在研究开始时，年龄在12-21岁的健康青少年至少进行了两次MRI扫描。主要终点为平均pv - pv体积（mm3/白质cm3）。结果：平均而言，男性在所有年龄段的mv - pv体积都比女性大。建立了mv - pv体积的线性混合效应模型。随着时间的推移，平均BMI和个人BMI的增加与mv - pv体积的增加有关。仅在女性中，BMI的变化与mv - pv体积相关。BMI高于一个人的平均BMI增加一个单位与mv - pv体积增加0.021 mm3/cm3相关（P < 0.001）。结论：这项纵向研究显示了青春期和青年期mv - pv特征的性别差异。重要的是，我们报告说，BMI从一个人的平均BMI增加只与女性的mv - pv体积增加有关。这些发现表明mv - pv、性别和BMI之间存在潜在联系，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.