Neuroprosthetic closed-loop strategy for sustained blood pressure reduction via simultaneous stimulation and recording from the spinal cord.

IF 6.9 2区医学 Q1 CLINICAL NEUROLOGY

Neurotherapeutics Pub Date : 2025-09-30 DOI:10.1016/j.neurot.2025.e00758

Mingeun Cho, Minhye Choo, Matthew Koh, Sunguk Hong, Junseung Mun, Juho Koo, ChangHwa Oh, Sung-Min Park

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Abstract

Sympathetic hyperactivity is a common feature observed in both primary and secondary hypertension, and neuromodulation-based therapies targeting this overactivity are under active investigation. The intermediolateral nucleus (IML) in the spinal cord plays a central role in sympathetic regulation, and its direct stimulation induces a transient, frequency-dependent reduction in blood pressure. However, this effect gradually diminishes as the baroreflex restores blood pressure to baseline. Therefore, this study aims to develop a closed-loop (CL) stimulation system that adjusts parameters in real-time based on neural activity recorded from the IML and to enhance and prolong the transient antihypertensive effect. This strategy was evaluated in normotensive and angiotensin II-induced hypertensive rat models and compared to open-loop (OL) stimulation of equal intensity. In both models, CL stimulation produced a more sustained blood pressure reduction than that of OL stimulation. These findings suggest that CL spinal cord stimulation offers a more effective and durable therapeutic option for treating hypertension.

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神经假体闭环策略通过同步刺激和脊髓记录持续降低血压。

交感神经过度活跃是原发性和继发性高血压的共同特征，针对这种过度活跃的基于神经调节的治疗正在积极研究中。脊髓中的中外侧核（IML）在交感神经调节中起着核心作用，它的直接刺激引起短暂的、频率依赖性的血压降低。然而，随着压力反射将血压恢复到基线水平，这种影响逐渐减弱。因此，本研究旨在开发一种闭环（CL）刺激系统，根据IML记录的神经活动实时调整参数，增强和延长短暂性降压效果。该策略在正常血压和血管紧张素ii诱导的高血压大鼠模型中进行了评估，并与等强度的开环（OL）刺激进行了比较。在两种模型中，CL刺激比OL刺激产生更持久的血压降低。这些结果表明，脊髓CL刺激为治疗高血压提供了更有效和持久的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotherapeutics 医学-神经科学

CiteScore

11.00

自引率

3.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.