Cancer stem cell analysis and targeting.

4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Methods in cell biology Pub Date : 2025-01-01 Epub Date: 2025-03-01 DOI:10.1016/bs.mcb.2025.02.017

Mishal Safdar, Zoya Amin, Muneeb Ullah, Abdul Wahab, Nurhasni Hasan, Muhammad Naeem

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引用次数: 0

Abstract

Tumor cells generate a type of cell called Cancer stem cells (CSCs) having self-renewal and differentiation properties, tumor initiation, metastasis and progression, as well as therapeutic resistance. CSCs analysis and targeting are efficient ways in developing more effective therapeutics. In this book we will elaborate on the recent advancement in CSCs analysis like surface marker analysis, functional analysis, molecular techniques, as well as different cancer cell analysis. And elaborate the different therapeutic targeting strategies of CSCs like targeting surface cellular markers, ATP-driven efflux transporters, key signaling cascades, and tumor microenvironments. The chapter also addresses the challenges of CSC research, including cellular heterogeneity and resistance to conventional therapies, and discusses future directions to enhance CSC targeting efficacy. Real-world case studies and clinical trials provide practical insights, underscoring the potential of CSC-focused therapies to transform cancer treatment and advance towards more personalized and effective therapeutic strategies.

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癌症干细胞分析和靶向。

肿瘤细胞产生一种称为癌症干细胞（Cancer stem cells, CSCs）的细胞，具有自我更新和分化特性，肿瘤的发生、转移和进展，以及治疗抗性。CSCs分析和靶向是开发更有效的治疗方法的有效途径。在这本书中，我们将详细介绍CSCs分析的最新进展，如表面标记分析、功能分析、分子技术以及不同的癌细胞分析。并详细阐述CSCs的不同治疗靶向策略，如靶向表面细胞标记物、atp驱动的外排转运体、关键信号级联和肿瘤微环境。本章还讨论了CSC研究的挑战，包括细胞异质性和对常规治疗的耐药性，并讨论了未来增强CSC靶向疗效的方向。现实世界的案例研究和临床试验提供了实用的见解，强调了以csc为重点的治疗方法在改变癌症治疗方面的潜力，并朝着更加个性化和有效的治疗策略迈进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Methods in cell biology 生物-细胞生物学

CiteScore

3.10

自引率

0.00%

发文量

125

审稿时长

3 months

期刊介绍： For over fifty years, Methods in Cell Biology has helped researchers answer the question "What method should I use to study this cell biology problem?" Edited by leaders in the field, each thematic volume provides proven, state-of-art techniques, along with relevant historical background and theory, to aid researchers in efficient design and effective implementation of experimental methodologies. Over its many years of publication, Methods in Cell Biology has built up a deep library of biological methods to study model developmental organisms, organelles and cell systems, as well as comprehensive coverage of microscopy and other analytical approaches.