B. Labella , G. Brochier , M. Beuvin , A. Chanut , E. Lacene , C. Labasse , A. Madelaine , F. Levy-Borsato , S. Leonard-Louis , G. Bassez , D. Seilhean , T. Evangelista
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引用次数: 0
Abstract
Open muscle biopsy (OBM) is a valuable diagnostic tool, but patients frequently express concerns about the surgical risks and potential discomfort. The aim of this observational study is to describe the characteristics of pain encountered during and after OBM and to assess the prognostic factors that may influence patient’s pain perception. Patients aged > 18 years who underwent OBM at the Pitié-Salpêtrière Hospital in Paris and provided informed consent were enrolled in the study. Clinical data and frailty assessment were collected prior to the intervention. Following OBM, patients completed a detailed questionnaire, including the numerical rating scale (NRS) for pain assessment, and the PHQ-9 questionnaire. Follow-up phone calls were performed at 15 and 30 days. Eighty-four patients (25 males) were enrolled, with a mean pain score of 2.5 on the NRS. The most painful phase of the OBM was the sampling collection phase (52/84, 61.9%), followed by the local anesthesia phase (17/84, 20.2%). Overall global satisfaction, including medical communication, service comfort and biopsy procedure, was rated as 9/10. No major complications were observed in the follow-up period, available for 63 patients. Twenty-one patients (38.8%) reported mild pain (NRS 1-3), usually lasting up to 48 hours, while eight patients (12.7%) experienced moderate pain (NRS 4-6). Overall, only twenty-four patients (38.1%) took an antalgic treatment after OBM, with paracetamol being the first line analgesic (22/24, 91.4%), yielding a good therapeutic response. Pre-interventional anxiety wasn’t associated with higher pain perception during OBM. Pain experienced during OBM is usually mild. After OBM, patients generally report little to no discomfort. Therefore, OBM is a safe and well-tolerated procedure.
期刊介绍:
This international, multidisciplinary journal covers all aspects of neuromuscular disorders in childhood and adult life (including the muscular dystrophies, spinal muscular atrophies, hereditary neuropathies, congenital myopathies, myasthenias, myotonic syndromes, metabolic myopathies and inflammatory myopathies).
The Editors welcome original articles from all areas of the field:
• Clinical aspects, such as new clinical entities, case studies of interest, treatment, management and rehabilitation (including biomechanics, orthotic design and surgery).
• Basic scientific studies of relevance to the clinical syndromes, including advances in the fields of molecular biology and genetics.
• Studies of animal models relevant to the human diseases.
The journal is aimed at a wide range of clinicians, pathologists, associated paramedical professionals and clinical and basic scientists with an interest in the study of neuromuscular disorders.