SINGLE-CELL MULTIOMIC APPROACHES FOR UNDERSTANDING HUMAN BRAIN VARIABILITY IN HEALTH AND DISEASE

IF 6.7 2区医学 Q1 CLINICAL NEUROLOGY

European Neuropsychopharmacology Pub Date : 2025-10-01 DOI:10.1016/j.euroneuro.2025.08.509

Margarita Behrens

引用次数: 0

Abstract

Diversity and individual variability are essential to human cognitive function. Identifying the conserved and variable transcriptomic and epigenomic signatures of the brain’s cellular components is critical for understanding the neurobiological basis of individual variation and how this changes with age and in mental disorders. We will discuss results from a multiomic single-cell epigenome and transcriptome analyses performed on brain samples with sex and age diversity, and show they provide new insight into the diversity of brain-cell molecular identity across individuals. As well, we will discuss age-related changes in the epigenome of specific cell-types in relation to neurological disorders.

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单细胞多组学方法用于理解人类大脑在健康和疾病中的变异性

多样性和个体可变性对人类认知功能至关重要。识别大脑细胞成分的保守和可变转录组学和表观基因组特征对于理解个体变异的神经生物学基础以及这种变异如何随年龄和精神障碍而变化至关重要。我们将讨论对具有性别和年龄多样性的脑样本进行的多组单细胞表观基因组和转录组分析的结果，并表明它们为个体之间脑细胞分子身份的多样性提供了新的见解。此外，我们将讨论与神经系统疾病相关的特定细胞类型表观基因组的年龄相关变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Neuropsychopharmacology 医学-精神病学

CiteScore

10.30

自引率

5.40%

发文量

730

审稿时长

41 days

期刊介绍： European Neuropsychopharmacology is the official publication of the European College of Neuropsychopharmacology (ECNP). In accordance with the mission of the College, the journal focuses on clinical and basic science contributions that advance our understanding of brain function and human behaviour and enable translation into improved treatments and enhanced public health impact in psychiatry. Recent years have been characterized by exciting advances in basic knowledge and available experimental techniques in neuroscience and genomics. However, clinical translation of these findings has not been as rapid. The journal aims to narrow this gap by promoting findings that are expected to have a major impact on both our understanding of the biological bases of mental disorders and the development and improvement of treatments, ideally paving the way for prevention and recovery.