Enantioselective Synthesis of Atropisomeric 3-Arylindoles via Cobalt-Catalyzed Electroreductive Cross-Coupling.

Abstract

Cobalt-catalyzed enantioselective electroreductive cross-coupling of aryl iodides and indole bromides has been developed. This strategy is characterized by mild reaction conditions, high enantioselectivities, and a broad substrate scope. Notably, this approach effectively addresses the challenges associated with indole substrates that do not possess electron-withdrawing substituents at the 2-position, a limitation that remains unresolved in other strategies.