Andrea Salotti, Lucrezia Mondini, Paola Confalonieri, Francesco Salton, Chiara Nalli, Nicolò Reccardini, Chiara Torregiani, Caterina Antonaglia, Michael Hughes, Marco Confalonieri, Rossella Cifaldi, Barbara Ruaro
{"title":"Cardiac sarcoidosis recurrence post-heart transplant: A critical literature and case report.","authors":"Andrea Salotti, Lucrezia Mondini, Paola Confalonieri, Francesco Salton, Chiara Nalli, Nicolò Reccardini, Chiara Torregiani, Caterina Antonaglia, Michael Hughes, Marco Confalonieri, Rossella Cifaldi, Barbara Ruaro","doi":"10.36141/svdld.v42i3.16865","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aim: </strong>Recurrence of cardiac sarcoidosis (CS) following heart transplantation (HT) is a rare but clinically significant complication that influences management strategies and prognosis. This review examines existing evidence on the diagnosis and treatment of post-transplant CS recurrence. Additionally, we present a case report of CS recurrence in a patient after HT.</p><p><strong>Methods: </strong>We analyzed clinical studies, case reports, and systematic reviews published up to January 2025, focusing on the recurrence of CS after transplantation.</p><p><strong>Results: </strong>Limited data suggest that immunosuppressive therapies are crucial in managing post-transplant CS recurrence. Diagnosis relies on imaging modalities such as Positron Emission Tomography (PET-CT), Cardiac Magnetic Resonance (CMR), and endomyocardial biopsies. Treatment generally involves intensifying immunosuppressive therapy.</p><p><strong>Conclusions: </strong>Standardized guidelines are essential to improve the management of this rare and complex condition and to enhance long-term patient outcomes.</p>","PeriodicalId":502142,"journal":{"name":"Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG","volume":"42 3","pages":"16865"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536832/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36141/svdld.v42i3.16865","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background and aim: Recurrence of cardiac sarcoidosis (CS) following heart transplantation (HT) is a rare but clinically significant complication that influences management strategies and prognosis. This review examines existing evidence on the diagnosis and treatment of post-transplant CS recurrence. Additionally, we present a case report of CS recurrence in a patient after HT.
Methods: We analyzed clinical studies, case reports, and systematic reviews published up to January 2025, focusing on the recurrence of CS after transplantation.
Results: Limited data suggest that immunosuppressive therapies are crucial in managing post-transplant CS recurrence. Diagnosis relies on imaging modalities such as Positron Emission Tomography (PET-CT), Cardiac Magnetic Resonance (CMR), and endomyocardial biopsies. Treatment generally involves intensifying immunosuppressive therapy.
Conclusions: Standardized guidelines are essential to improve the management of this rare and complex condition and to enhance long-term patient outcomes.
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