CXCR7 Facilitates the Migration and Proliferation of UCMSCs via β-Catenin/TCF4/MDM2 Signal Regulating Notch1 Ubiquitination to Ameliorate Pulmonary Fibrosis in ARDS
Yan Cao, Zhirong Qian, Yuwei Yang, Jiahui Jin, David Y. B. Deng, Shuning Zhang, Lixin Xie, Kun Xiao
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引用次数: 0
Abstract
Umbilical cord mesenchymal stem cells (UCMSCs) hold therapeutic potential for acute respiratory distress syndrome (ARDS), but the role of atypical CXC chemokine receptor 7 (CXCR7) in their homing and reparative effects remains unclear. Using a lipopolysaccharide (LPS)-induced ARDS mouse model, we demonstrated that CXCR7 overexpression enhances UCMSC proliferation, migration, and lung repair. Mechanistically, CXCR7 activates the Wnt/β-catenin pathway to upregulate murine double minute (MDM2) transcription, which subsequently ubiquitinates and degrades Notch1, revealing a novel Wnt-Notch crosstalk. These findings highlight CXCR7 as a therapeutic target for ARDS and provide insights into UCMSC-based regenerative strategies.
期刊介绍：
The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.
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