Guarding masculinity: telmisartan and aerobic exercise preserve testicular histomorphometry in diabetic rats.

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Archivio Italiano di Urologia e Andrologia Pub Date : 2025-09-30 DOI:10.4081/aiua.2025.14142

Ali Akbar Firasi, Mohammad Ayodhia Soebadi, Soetojo Wirjopranoto, Ghazian Adli, Anny Setijo Rahaju

{"title":"Guarding masculinity: telmisartan and aerobic exercise preserve testicular histomorphometry in diabetic rats.","authors":"Ali Akbar Firasi, Mohammad Ayodhia Soebadi, Soetojo Wirjopranoto, Ghazian Adli, Anny Setijo Rahaju","doi":"10.4081/aiua.2025.14142","DOIUrl":null,"url":null,"abstract":"Background: diabetes mellitus (DM) is associated with testicular damage, leading to male infertility. This study investigates the effects of telmisartan, moderate-intensity aerobic exercise, and their combination on testicular histopathology in a streptozotocin-induced diabetic rat model.Methods: male Wistar rats were divided into five groups: healthy control (K0), diabetic control (K1), telmisartan monotherapy (K2), aerobic exercise monotherapy (K3), and combination therapy (K4). Diabetes was induced using streptozotocin (STZ), and treatments were administered for 10 weeks. Testicular histopathology was assessed by evaluating Johnsen score, Sertoli cell count, Leydig cell count, and seminiferous tubule diameter.Results: diabetic rats (K1) showed significant declines in Johnsen score, Sertoli and Leydig cell counts, and seminiferous tubule diameter (p<0.05). Telmisartan (K2) and combination therapy (K4) significantly improved all parameters, with values approaching those of healthy controls (K0). Aerobic exercise (K3) improved seminiferous tubule diameter but had limited effects on Johnsen score, Sertoli, and Leydig cells. Kruskal- Wallis, Mann-Whitney U, ANOVA, Games-Howell, and LSD tests confirmed these findings.Conclusions: Telmisartan, either as monotherapy or in combination with moderate-intensity aerobic exercise, effectively ameliorates testicular damage in diabetic rats. Aerobic exercise alone has a partial protective effect. These findings suggest potential therapeutic strategies for preventing diabetes-induced male infertility.","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":"97 3","pages":"14142"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivio Italiano di Urologia e Andrologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/aiua.2025.14142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: diabetes mellitus (DM) is associated with testicular damage, leading to male infertility. This study investigates the effects of telmisartan, moderate-intensity aerobic exercise, and their combination on testicular histopathology in a streptozotocin-induced diabetic rat model.

Methods: male Wistar rats were divided into five groups: healthy control (K0), diabetic control (K1), telmisartan monotherapy (K2), aerobic exercise monotherapy (K3), and combination therapy (K4). Diabetes was induced using streptozotocin (STZ), and treatments were administered for 10 weeks. Testicular histopathology was assessed by evaluating Johnsen score, Sertoli cell count, Leydig cell count, and seminiferous tubule diameter.

Results: diabetic rats (K1) showed significant declines in Johnsen score, Sertoli and Leydig cell counts, and seminiferous tubule diameter (p<0.05). Telmisartan (K2) and combination therapy (K4) significantly improved all parameters, with values approaching those of healthy controls (K0). Aerobic exercise (K3) improved seminiferous tubule diameter but had limited effects on Johnsen score, Sertoli, and Leydig cells. Kruskal- Wallis, Mann-Whitney U, ANOVA, Games-Howell, and LSD tests confirmed these findings.

Conclusions: Telmisartan, either as monotherapy or in combination with moderate-intensity aerobic exercise, effectively ameliorates testicular damage in diabetic rats. Aerobic exercise alone has a partial protective effect. These findings suggest potential therapeutic strategies for preventing diabetes-induced male infertility.

查看原文本刊更多论文

保护阳刚之气：替米沙坦和有氧运动保护糖尿病大鼠睾丸组织形态。

背景：糖尿病（DM）与睾丸损伤相关，可导致男性不育。本研究探讨替米沙坦、中强度有氧运动及其联合用药对链脲佐菌素诱导的糖尿病大鼠睾丸组织病理学的影响。方法：雄性Wistar大鼠分为健康对照组（K0）、糖尿病对照组（K1）、替米沙坦单药治疗组（K2）、有氧运动单药治疗组（K3）和联合治疗组（K4）。采用链脲佐菌素（STZ）诱导糖尿病，治疗10周。通过Johnsen评分、支持细胞计数、间质细胞计数和精小管直径评估睾丸组织病理学。结果：糖尿病大鼠（K1）的Johnsen评分、Sertoli和Leydig细胞计数、精小管直径均显著下降(结论：替米沙坦单药或与中强度有氧运动联合用药均可有效改善糖尿病大鼠睾丸损伤。仅有氧运动就有部分保护作用。这些发现为预防糖尿病引起的男性不育提供了潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊