The role of non-coding RNAs in pleural mesothelioma

IF 5 2区医学 Q2 Medicine

Translational Oncology Pub Date : 2025-09-29 DOI:10.1016/j.tranon.2025.102547

Giulia Tonnini , Giulia Di Mauro , Maria Letizia Tramarin , Anna Meneghetti , Ilaria Bononi , Chiara Mazziotta , John Charles Rotondo , Elisa Mazzoni , Maria Rosa Iaquinta , Elisabetta Trabetti , Cristina Bombieri , Monica De Mattei , Mauro Tognon , Fernanda Martini

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引用次数: 0

Abstract

Background

Pleural mesothelioma (PM) is a rare and highly aggressive tumor, primarily caused by asbestos exposure. Its long latency period and late-stage diagnosis severely limit therapeutic options.

Aim

Recent evidence suggests that non-coding RNAs (ncRNAs)—including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs)—play key roles in PM biology. This review aims to synthesize current knowledge on ncRNA dysregulation in PM and explore their diagnostic, prognostic, and therapeutic potential.

Scope

We summarize studies addressing the expression and function of ncRNAs in tumors and in circulating biofluids of PM patients. Particular attention is given to how ncRNAs regulate proliferation, apoptosis, and migration, and how competing endogenous RNA (ceRNA) networks shape gene regulation in PM.

Novelty and Conclusion

Unlike previous reviews, this work integrates findings across different classes of ncRNAs and their interactions, highlighting the emerging concept of ceRNA networks in PM. By bridging molecular mechanisms with potential clinical applications, we provide an updated and comprehensive framework that may inform future strategies for diagnosis, prognosis, and targeted therapy in PM.

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非编码rna在胸膜间皮瘤中的作用。

背景：胸膜间皮瘤（PM）是一种罕见的高侵袭性肿瘤，主要由石棉暴露引起。它的潜伏期长和晚期诊断严重限制了治疗选择。目的：最近的证据表明，非编码rna (ncRNAs)-包括microRNAs (miRNAs), long ncRNAs （lncRNAs）和circular RNAs (circRNAs)-在PM生物学中发挥关键作用。本综述旨在综合目前关于PM中ncRNA失调的知识，并探讨其诊断、预后和治疗潜力。范围：我们总结了ncRNAs在肿瘤和PM患者循环体液中的表达和功能的研究。特别关注ncRNAs如何调节增殖、凋亡和迁移，以及竞争的内源性RNA （ceRNA）网络如何影响PM中的基因调控。新颖性和结论：与之前的综述不同，这项工作整合了不同类别的ncrna及其相互作用的发现，突出了PM中ceRNA网络的新兴概念。通过将分子机制与潜在的临床应用联系起来，我们提供了一个更新和全面的框架，可以为PM的诊断，预后和靶向治疗提供未来的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Oncology ONCOLOGY-

CiteScore

8.40

自引率

2.00%

发文量

314

审稿时长

54 days

期刊介绍： Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.