Interconnection between gut microbial metabolites and mitochondrial ROS production: implications for cellular health.

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Priyanka Gupta, Sumit Dutta, Krishanu Dutta, Piyush Bhattacharjee, Arjama Hazra, Rajiv Jash
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引用次数: 0

Abstract

Trillions of microbes inhabit the human gut and engage in diverse biological processes by secreting different metabolites. These metabolites influence mitochondrial function and produce ROS. This gut-mitochondrial communication plays a pivotal role in regulating cellular homeostasis, energy production, and oxidative stress management, all required for optimal health. Short-chain fatty acids, secondary bile acids, amines, and gaseous metabolites are major gut metabolites that aid in governing mitochondrial processes to facilitate effective energy production and avoid oxidative damage. In the case of damaged mitochondrial function, it can alter gut flora (dysbiosis), resulting in inflammation and assisting a number of diseases such as multiple sclerosis, Alzheimer's disease, IgA nephropathy, inflammatory bowel disease, and colorectal cancer. The gut-mitochondria axis is a multifaceted interaction that regulates a cell's energy homeostasis and provides novel therapeutic opportunities. Probiotics, prebiotics, dietary modifications, and metabolite therapies have the potential to restore gut-microbe balance, enhance mitochondrial function, and reduce oxidative stress. These measures have the potential for new treatments for many diseases by modulating the gut-mitochondria axis. This review surveys interactions among gut microbiota, mitochondrial ROS, and the gut-mitochondria axis, describing how such relationships affect health and disease.

肠道微生物代谢物和线粒体活性氧产生之间的相互联系:对细胞健康的影响。
数以万亿计的微生物栖息在人体肠道中,通过分泌不同的代谢物参与多种生物过程。这些代谢物影响线粒体功能并产生活性氧。这种肠道-线粒体通讯在调节细胞稳态、能量产生和氧化应激管理中起着关键作用,这些都是最佳健康所必需的。短链脂肪酸、次级胆汁酸、胺和气态代谢物是主要的肠道代谢物,有助于控制线粒体过程,促进有效的能量产生,避免氧化损伤。在线粒体功能受损的情况下,它可以改变肠道菌群(生态失调),导致炎症并帮助许多疾病,如多发性硬化症、阿尔茨海默病、IgA肾病、炎症性肠病和结直肠癌。肠道-线粒体轴是一个多方面的相互作用,调节细胞的能量稳态,并提供新的治疗机会。益生菌、益生元、饮食调整和代谢物疗法具有恢复肠道微生物平衡、增强线粒体功能和减少氧化应激的潜力。这些措施有可能通过调节肠道-线粒体轴来治疗许多疾病。这篇综述调查了肠道微生物群、线粒体ROS和肠道-线粒体轴之间的相互作用,描述了这种关系如何影响健康和疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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