DKA with negative DM-autoantibodies, complicated by GBS and RESLES: a case report and literature review.

IF 5.9 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI:10.3389/fimmu.2025.1597365

Nan Tian, Yanwen Yang, Qiang Liu, Zeli Ma, Ying Wang, Xuan Li, Xu Wang, Yanzi Jin, Rong Chen, Yajun Li, Fenkui She, Fenglin Mou, Qing Zhang

引用次数: 0

Abstract

Guillain-Barré syndrome (GBS) is an autoimmune-mediated disorder characterized by acute, multifocal peripheral neuropathies, typically triggered by infections, autoimmune diseases, or immunosuppressive therapies. In this report, we describe a patient newly diagnosed with diabetes mellitus (DM) and diabetic ketoacidosis (DKA), who presented with negative insulin-related autoantibodies and no identifiable infectious etiology. It is suggested that DKA may independently contribute to the development of GBS. Additionally, DKA can lead to the reversible splenial lesion syndrome (RESLES). We present a case of GBS with atypical features consistent with the acute motor axonal neuropathy (AMAN) variant.

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DKA合并dm自身抗体阴性，合并GBS和RESLES 1例报告并文献复习。

格林-巴勒综合征（GBS）是一种自身免疫介导的疾病，以急性多灶周围神经病变为特征，通常由感染、自身免疫性疾病或免疫抑制疗法引发。在这个报告中，我们描述了一个新诊断为糖尿病（DM）和糖尿病酮症酸中毒（DKA）的患者，他表现为胰岛素相关自身抗体阴性，没有可识别的感染病因。这表明DKA可能独立地促进了GBS的发展。此外，DKA可导致可逆性脾损害综合征（RESLES）。我们提出了一例GBS的不典型特征与急性运动轴索神经病（AMAN）变体一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.