Modified recombinant collagen-peptide/gallic acid grafted chitosan composites with antibacterial and antioxidant property for wound dressing: a preliminary study.
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Abstract
Chronic wounds pose a persistent clinical challenge, primarily due to prolonged bacterial infections. The development of natural antibacterial dressings offers a promising strategy for their effective management. In this study, recombinant human collagen methacrylamide (RHCMA) and gallic acid-grafted chitosan (CSGA) were synthesized and subsequently crosslinked via UV irradiation to form a composite hydrogel (RHCMA-CSGA). The composition and structure of the hydrogel were systematically characterized. Its cytocompatibility and antibacterial properties were also evaluated. The results demonstrated that the hydrogel exhibited excellent biocompatibility and strong antibacterial activity. These findings suggest that the RHCMA-CSGA hydrogel holds great potential as a therapeutic dressing for chronic wound healing.
期刊介绍：
Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.
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