Novel tumor-infiltrating lymphocytes therapy in solid tumors: latest updates from 2025 ASCO annual meeting.

IF 13.5 1区医学 Q1 HEMATOLOGY

Experimental Hematology & Oncology Pub Date : 2025-09-30 DOI:10.1186/s40164-025-00711-x

Yanan Ma, Xuan Su, Huijing Feng

引用次数: 0

Abstract

Tumor-infiltrating lymphocyte (TIL) therapy, a highly promising form of adoptive cell therapy (ACT), has demonstrated success in treating advanced melanoma. Notably, innovative TIL-based monotherapies and combination regimens have provided durable clinical responses and survival benefits for patients with various solid tumors. This article summarizes recent advances in TIL therapy for solid tumors presented at the 2025 ASCO Annual Meeting, highlighting monotherapies such as Lifileucel, LM103, OBX-115, GT101, GT300, GT201, and HS-IT101, as well as combination strategies with the oncolytic adenovirus TILT-123 or pembrolizumab.

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新型肿瘤浸润淋巴细胞治疗实体瘤：来自2025年ASCO年会上的最新进展。

肿瘤浸润淋巴细胞（TIL）治疗是一种非常有前途的过继细胞治疗（ACT）形式，已经证明在治疗晚期黑色素瘤方面取得了成功。值得注意的是，创新的基于til的单药治疗和联合治疗方案为各种实体瘤患者提供了持久的临床反应和生存益处。本文总结了在2025年ASCO年会上公布的TIL治疗实体瘤的最新进展，重点介绍了Lifileucel、LM103、OBX-115、GT101、GT300、GT201和HS-IT101等单药治疗，以及与溶瘤腺病毒TILT-123或pembrolizumab的联合治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Hematology & Oncology Medicine-Oncology

CiteScore

12.60

自引率

7.30%

发文量

审稿时长

6 weeks

期刊介绍： Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings. Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.