Association between serum albumin to serum creatinine ratio and incident heart failure in patients with chronic kidney disease.

IF 3.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2025-12-31 Epub Date: 2025-09-30 DOI:10.1080/10641963.2025.2561908

Weiwei Zhang, Youyou Liang, Peishan Xue, Chunlan Ma, Jing Zeng, Yali Qu, Yuting Zeng, Yingying Huang, Linhui He, Yuanyuan Jiang

引用次数: 0

Abstract

This prospective cohort study investigated the association between the albumin to serum creatinine ratio (sACR) and heart failure (HF) incidence in 150 chronic kidney disease (CKD) patients. Over a median 23-month follow-up, 114 HF events occurred. Multivariate Cox regression revealed a higher HF risk in the lowest versus highest sACR tertile (adjusted HR=1.742, 95% CI=1.341-2.002, p=0.023). Lower sACR correlated with worsened cardiac structure/function. The predictive AUC for HF was 0.64 for sACR alone and improved to 0.79 when combined with clinical covariates. We conclude that low sACR is independently associated with increased HF incidence in CKD patients.

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慢性肾病患者血清白蛋白与血清肌酐比值与心力衰竭的关系

本前瞻性队列研究调查了150例慢性肾脏疾病（CKD）患者白蛋白与血清肌酐比值（sACR）与心力衰竭（HF）发生率之间的关系。在平均23个月的随访中，发生了114例心衰事件。多因素Cox回归显示，sACR水平最低的组与sACR水平最高的组相比，HF风险更高（校正后HR=1.742, 95% CI=1.341-2.002, p=0.023）。较低的sACR与心脏结构/功能恶化相关。单独使用sACR预测HF的AUC为0.64，结合临床协变量后提高到0.79。我们得出结论，低sACR与CKD患者HF发病率增加独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.