Chengqing Liu, Lu Ding, Shangke Chen, Lu Liu, Xiang Zeng, Qi Yan, Jiabo Wang, Nazila Saitiniaz, Nan Yang, Xiaoya Xu, Yuming Mu, Zhen Chen, Rong Li
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引用次数: 0
Abstract
Patients with advanced cervical cancer have a poor prognosis, and sonodynamic therapy (SDT) is expected to offer a new approach for improving the therapeutic outcome of cervical cancer due to its noninvasiveness and ability to penetrate deeply into tissues. In order to overcome the problems of the rapid elimination and low water solubility of organic acoustic sensitizers in SDT, DSPE-PEG2000-coated tetragonal-phase barium titanate nanoparticles (BTO@PEG) were employed in this study to replace the conventional nanoacoustic sensitizers. It was found that BTO@PEG could continuously generate ROS through SDT and the piezoelectric effect under ultrasound (US) stimulation, which subsequently promoted the apoptosis of cervical cancer cells and inhibited the growth of subcutaneously transplanted HeLa-derived cervical cancer tumors in nude mice. BTO@PEG showed good biocompatibility, as confirmed by cytology and animal experiments.
期刊介绍：
Molecular Pharmaceutics publishes the results of original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. The journal encourages contributions describing research at the interface of drug discovery and drug development.
Scientific areas within the scope of the journal include physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science as they relate to drug and drug delivery system efficacy. Mechanistic Drug Delivery and Drug Targeting research on modulating activity and efficacy of a drug or drug product is within the scope of Molecular Pharmaceutics. Theoretical and experimental peer-reviewed research articles, communications, reviews, and perspectives are welcomed.
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