Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06)

Xiao Duan, Mo Zhu, Shiqiang Gao
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Abstract

Illuminating Life with Optogenetics

Beams of light orchestrate cellular control: light-gated ion channels shape ion flux; photoswitchable enzymes and receptors modulate signaling pathways; light-controlled protein interactions tune function; and light-regulated gene expression. In article 202500021, Xiao Duan, Mo Zhu, and Shiqiang Gao review two decades of optogenetics, from fundamental biology to early clinical translation. The cover image is based on the article Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead by Xiao Duan et al., https://doi.org/10.1002/ggn2.202500021.

Abstract Image

光遗传学工具的二十年:回顾与展望(高级遗传学3/06)
光遗传学照亮生命光束协调细胞控制:光门控离子通道塑造离子通量;光开关酶和受体调节信号通路;光控蛋白相互作用调控功能;以及光调控基因表达。在文章202500021中,段晓、朱默和高世强回顾了二十年来光遗传学从基础生物学到早期临床转化的研究。封面图片基于Xiao Duan等人的文章《二十年的光遗传学工具:回顾与展望》(https://doi.org/10.1002/ggn2.202500021)。
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