{"title":"Strategies for the Synthesis of Alkylated Coumarins Using Various Alkyl Radical Precursors","authors":"Md. Belal","doi":"10.1002/jhet.70079","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Coumarins are known for their biological significance. Various coumarin derivatives are found in nature and they show intriguing biological activities. Several methods are reported in the literature for the construction of coumarins. Recently, an interesting feature of the motif has been realized that it can trap free radical species, especially alkyl radicals, thus it acts as a radical scavenger. Various alkylated coumarin derivatives have been constructed using coumarin as a sink for these radical species. In this review, recent developments in regioselective functionalization of coumarin derivatives using various precursors for the generation of alkyl radicals through distinct approaches have been compiled and critically reported to give a perspective about the development of new coumarin derivatives and their future scope.</p>\n </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1293-1300"},"PeriodicalIF":2.0000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.70079","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Coumarins are known for their biological significance. Various coumarin derivatives are found in nature and they show intriguing biological activities. Several methods are reported in the literature for the construction of coumarins. Recently, an interesting feature of the motif has been realized that it can trap free radical species, especially alkyl radicals, thus it acts as a radical scavenger. Various alkylated coumarin derivatives have been constructed using coumarin as a sink for these radical species. In this review, recent developments in regioselective functionalization of coumarin derivatives using various precursors for the generation of alkyl radicals through distinct approaches have been compiled and critically reported to give a perspective about the development of new coumarin derivatives and their future scope.
期刊介绍:
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.