Strategies for the Synthesis of Alkylated Coumarins Using Various Alkyl Radical Precursors

IF 2 3区 化学 Q2 CHEMISTRY, ORGANIC
Md. Belal
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Abstract

Coumarins are known for their biological significance. Various coumarin derivatives are found in nature and they show intriguing biological activities. Several methods are reported in the literature for the construction of coumarins. Recently, an interesting feature of the motif has been realized that it can trap free radical species, especially alkyl radicals, thus it acts as a radical scavenger. Various alkylated coumarin derivatives have been constructed using coumarin as a sink for these radical species. In this review, recent developments in regioselective functionalization of coumarin derivatives using various precursors for the generation of alkyl radicals through distinct approaches have been compiled and critically reported to give a perspective about the development of new coumarin derivatives and their future scope.

Abstract Image

利用各种烷基自由基前体合成烷基香豆素的策略
香豆素因其生物学意义而闻名。各种香豆素衍生物在自然界中被发现,它们显示出有趣的生物活性。文献中报道了几种构建香豆素的方法。近年来,人们认识到该基序的一个有趣的特点,即它可以捕获自由基,特别是烷基自由基,从而起到自由基清除剂的作用。利用香豆素作为这些自由基的汇,已经构建了各种烷基化香豆素衍生物。本文综述了香豆素衍生物区域选择性功能化的最新进展,综述了利用各种前体通过不同的方法生成烷基自由基的研究进展,并对香豆素衍生物的发展及其未来的发展前景进行了展望。
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来源期刊
Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry 化学-有机化学
CiteScore
5.20
自引率
4.20%
发文量
177
审稿时长
3.9 months
期刊介绍: The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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