Micro-/Nanomaterials for Surface-Enhanced Optical Biosensing

IF 7.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Jie Zhao, Xinyi Liu, Xujiang Yu, Wanwan Li
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引用次数: 0

Abstract

Optical biosensors are pivotal for their stability and high throughput, but their sensitivity often hinges on optical signal strength. Thanks to the combination of plasmonic nanostructures and spectroscopy, surface-enhanced spectroscopy (SES) has emerged as a powerful tool for identifying and characterizing trace molecular species with ultrahigh sensitivity. This technique holds broad application prospects in the field of optical biosensors, including surface-enhanced fluorescence (SEF), surface-enhanced Raman scattering (SERS), and surface-enhanced infrared absorption (SEIRA), which significantly improve the interaction intensity between photons and materials. This review elaborates on SES from the perspective of the combined system of SEF, SERS, and SEIRA, and summarizes the mechanism, micro-/nanomaterials structural design principles, and applications. A comprehensive review of the mechanisms from electromagnetic and chemical perspectives is provided. Reasonable micro/nanomaterial design strategies are then discussed to customize hot spots for different platforms with optimal enhancement. The review aims to emphasize the significant impact of micro-/nanomaterials in surface-enhanced optical biosensing. Besides, the progress of surface-enhanced biosensors around immunoassays, DNA/RNA, and other biomolecules is summarized. Finally, the challenges and future directions of the field are outlined.

Abstract Image

用于表面增强光学生物传感的微/纳米材料
光学生物传感器的稳定性和高通量是其关键,但其灵敏度往往取决于光信号强度。由于等离子体纳米结构与光谱学的结合,表面增强光谱(SES)已成为一种具有超高灵敏度的鉴定和表征痕量分子物种的有力工具。该技术在光学生物传感器领域具有广阔的应用前景,包括表面增强荧光(SEF)、表面增强拉曼散射(SERS)和表面增强红外吸收(SEIRA),它们显著提高了光子与材料之间的相互作用强度。本文从SEF、SERS和SEIRA复合体系的角度对SES进行了阐述,并对其机理、微/纳米材料结构设计原理及其应用进行了综述。从电磁和化学的角度对其机理进行了全面的综述。然后讨论了合理的微/纳米设计策略,以定制不同平台的热点,并进行最佳增强。本文旨在强调微/纳米材料在表面增强光学生物传感中的重要作用。综述了表面增强生物传感器在免疫检测、DNA/RNA等生物分子检测方面的研究进展。最后,概述了该领域面临的挑战和未来的发展方向。
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来源期刊
Advanced Optical Materials
Advanced Optical Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-OPTICS
CiteScore
13.70
自引率
6.70%
发文量
883
审稿时长
1.5 months
期刊介绍: Advanced Optical Materials, part of the esteemed Advanced portfolio, is a unique materials science journal concentrating on all facets of light-matter interactions. For over a decade, it has been the preferred optical materials journal for significant discoveries in photonics, plasmonics, metamaterials, and more. The Advanced portfolio from Wiley is a collection of globally respected, high-impact journals that disseminate the best science from established and emerging researchers, aiding them in fulfilling their mission and amplifying the reach of their scientific discoveries.
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