A Simple, Economical, and Green Protocol for the Synthesis of Benzyl-Quinoline Analogues by Grinding

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2025-08-07 DOI:10.1002/jhet.70052

Bathala Balaramudu, Chunduri Venkata Rao, Adapaka Venkateswara Rao, Suresh Maddila, Lalu Venigalla, Mohamed A. Nassan, Mohamed Mohamed Soliman

引用次数: 0

Abstract

A solvent-free, mechanochemical synthesis of benzyl-quinoline analogues is reported via a one-pot multicomponent reaction of substituted aldehydes, benzyl-3-oxobutanoate, 5-methylcyclohexane-1,3-dione, and ammonium acetate. Urea serves as an eco-friendly catalyst, enabling high yields (93%–97%) within 30 min under grinding conditions. This method eliminates column chromatography, reduces waste, and avoids toxic solvents or harsh conditions, offering a cost-effective and sustainable approach to quinoline derivatives.

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一种简单、经济、绿色的研磨法合成苯基喹啉类似物方案

报道了用取代醛、3-氧丁酸苄、5-甲基环己烷-1,3-二酮和乙酸铵进行一锅多组分反应，无溶剂机械化学合成了苯-喹啉类似物。尿素作为环保催化剂，在研磨条件下30分钟内可实现高收率（93%-97%）。该方法消除了柱层析，减少了浪费，避免了有毒溶剂或恶劣条件，为喹啉衍生物提供了经济高效且可持续的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.